Scaffolds for α-helix mimicry

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...

Reexamination Certificate

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C514S252020, C514S252030, C514S252010, C514S252050, C544S224000, C544S238000

Reexamination Certificate

active

07579350

ABSTRACT:
Functionalized pyridazine derivatives having a low molecular weight and pharmaceutical compositions thereof are useful as alpha-helix mimetics and for treating conditions and/or disorders mediated by alpha-helix-binding receptors and proteins.

REFERENCES:
patent: 56005480 (1981-10-01), None
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Ernst, et al., “Design of a Protein Surface Antagonist Based on α-Helix Mimicry: Inhibition of gp41 Assembly and Viral Fusion”,Angew. Chem. Int. Ed. 41: 278-281 (2002).
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Kim, et al., “Therapeutic Potential of Antisense Bcl-2 as a Chemosensitizer for Cancer Therapy”,Cancer 101: 2491-2502 (2004).

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