Saturation monitor and process

Details Saturation monitor and process Saturation monitor and process

1989-01-25

1990-03-06

Richman, Barry S.

Chemistry: analytical and immunological testing

Tracers or tags

436 79, 436164, 436179, 436181, 436183, 73 61R, G01N 3700, G01N 2117, G01N 3338

Patent

active

049065807

ABSTRACT:
A process for determining the degree of saturation of a solution comprising a solvent and a compound of limited solubility which involves the steps of (1) diluting a feed solution of the compound of limited solubility, (2) passing a sample of the diluted feed solution through a bed of a solid solution of the compound and a tracer in which the tracer is intrinsically incorporated into the crystal structure of the compound, so that the diluted feed solution being tested becomes saturated with the compound by dissolution of a portion of the solid solution in the bed, (3) measuring the concentration of the tracer in the sample after passage through the bed of solid solution, thus measuring the amount of the compound dissolved from the solid solution to saturate the diluted feed solution, and (4) determining the degree of saturation of the compound in the feed solution from the measured values.

REFERENCES:
patent: 3368389 (1968-02-01), Barnett
patent: 4226114 (1980-10-01), Hagedorn
patent: 4680271 (1987-07-01), Williams
Automated Dissolution Rate Studies of Capsules and Tablets by Schroeter and Wagner Jour. of Pharm. Sc. (RS 1.J58) Oct, 1962.

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