Sarcoma 180 tumor inhibitor and method of making same

Details Sarcoma 180 tumor inhibitor and method of making same Sarcoma 180 tumor inhibitor and method of making same

1978-03-29

1980-01-08

Goldberg, Jerome D.

Drug, bio-affecting and body treating compositions

Fermentate of unknown chemical structure

424 95, 424181, 435922, 435 68, A61K 3500

Patent

active

041827538

ABSTRACT:
A Sarcoma 180 tumor growth inhibiting glycoprotein material produced extracellularly from Candida albicans is provided. The inhibitor material is effective to arrest Sarcoma 180 tumor angiogenesis thereby causing tumor regression. The preferred inhibitor material is an extracellular glycoprotein produced from Candida albicans SA#1 (CBS 5736) cultured in a glucose containing chemical medium with a filtrate of the growth medium precipitated with ethanol. Dosage innoculations of the precipitate into the peritoneal cavities of Sarcoma 180 tumor infected mice effect substantial tumor regression.

REFERENCES:
Suzuki et al., Gann, 60: 65-69, Feb. 1969.

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