Sarcoidosis test

Details Sarcoidosis test Sarcoidosis test

1976-07-15

1978-08-22

Naff, David M.

Textiles: fiber preparation

424 7, G01N 3114

Patent

active

041087267

ABSTRACT:
Serum angiotensin converting enzyme is elevated in many patients with sarcoidosis. A method involving formation of the fluorescent adduct of o-phthaldialdehyde and the histidyl moiety of the L-histidyl-L-leucine product formed by the action of angiotensin converting enzyme on hippuryl-L-histidyl-L-leucine substrate is applicable to determining angiotensin converting enzyme in untreated serum for the diagnosis of sarcoidosis. This method is simple, rapid and highly sensitive, and requires as little as one ul or less of a serum.

REFERENCES:
piquilloud, et al., Studies on the Angiotensin Converting Enzyme with Different Substrates, Biochimica et Biophysica Acta, vol. 206, 1970 (pp. 136-142).
Cheung et al., Inhibition of Homogeneous Angiotensin-Converting Enzyme of Rabbit Lung by Synthetic Venom Peptides of Bothrops Jararaca, Biochimica et Biophysica Acta, vol. 293, 1973 (pp. 451-463).

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