Sapphyrin derivatives and conjugates

Details Sapphyrin derivatives and conjugates Sapphyrin derivatives and conjugates

1992-10-21

1995-10-10

Shah, Mukund J.

Organic compounds -- part of the class 532-570 series

Organic compounds

Unsubstituted hydrocarbyl chain between the ring and the -c-...

540145, C07D48722

Patent

active

054571952

ABSTRACT:
The present invention provides various covalently modified sapphyrin derivatives and conjugates, and also, polymers including sapphyrin or derivatives thereof. Disclosed are water soluble sapphyrins, including polyhydroxysapphyrins and sapphyrin-sugar derivatives; sapphyrin-metal chelating conjugates; sapphyrin nucleobase conjugates; and polymer supported sapphyrins. Novel sapphyrin dimers, trimers, oligomers and polymers are also described, which polymers may include repeating units of sapphyrin or sapphyrin derivatives alone, or may further incorporate other units such as nucleobases.

REFERENCES:
patent: 4833790 (1989-11-01), Levy et al.
patent: 4935498 (1990-06-01), Sessler et al.
patent: 5041078 (1991-08-01), Matthews et al.
patent: 5162509 (1992-11-01), Sessler et al.
patent: 5252720 (1993-10-01), Sessler et al.
International Search Report, mailed Feb. 3, 1994.
Aoyama, et al., "Multi-Point Interaction of Phosphates with Protonated Pyridylporphyrin. Discrimination of Monoalkyl and Dialkyl Phosphates," Chemistry Letters, 1991, 1241-1244.
Bauer et al., "Sapphyrins: Novel Aromatic Pentapyrrolic Macrocycles," J. Am. Che. Soc., 1983, 105:6429-6436.
Broadhurst and Grigg, "18- and 22-.pi.-Electron Macrocycles Containing Furan, Pyrrole, and Thiophen," Chemical Communications, 1969, 1480-1482.
Broadhurst and Grigg, "The Synthesis of 22 .pi.-Electron Macrocycles. Sapphyrins and Related Compounds," J.C.S. Perkin, 2111-2116, 1972.
Claude et al., "Binding of Nucleosides, Nucleotides and Anionic Planar Substrates by Bis-Intercaland Receptor Molecules," J. Chem. Soc, Chem. Commun., 1991, 17:1182-1185.
Cramer et al., "Synthesis and Structure of the Chloride and Nitrate Inclusion Complexes of [16-Pyrimidinium crown-4]," J. Am. Chem. Soc., 1991, 113:7033-7034.
Cuellar and Marks, "Synthesis and Characterization of Metallo and Metal-Free Octaalkylphthalocyanines and Uranyl Decaalkylsuperphthalocyanines," Inorg. Chem., 1981, 20:3766-3770.
Dietrich et al., "Proton Coupled Membrane Transport of Anions Mediated by Cryptate Carriers," J. Chem. Soc. Chem. Comm., 1988, 11:691-692.
Dixon et al., "Molecular Recognition: Bis-Acylguanidiniums Provide a Simple Family of Receptors for Phosphodiesters," J. Am. Chem. Soc., 1992, 114:365-366.
Furuta et al., "Phosphate Anion Binding: Enhanced Transport of Nucleotide Monophosphates Using a Sapphyrin Carrier," Journal of the American Chemical Society, 1991, 113:6677-6678.
Furuta et al., "Enhanced Transport of Nucleosides and Nucleoside Analogues with Complementary Base-Pairing Agents," Journal of the American Chemical Society, 1991, 113:4706-4707.
Galan et al., "A Synthetic Receptor for Dinucleotides," J. Am. Chem. Soc., 1991, 113:9424-9425.
Galan et al., "Selective Complexation of Adenosine Monophosphate Nucleotides By Rigid Bicyclic Guanidinium Abiotic Receptors," Tetrahedron Letters, 32(15):1827-1830, 1991.
Harriman et al., "Metallotexaphyrins: A New Family of Photosensitisers for Efficient Generation of Singlet Oxygen," J. Chem. Soc. Chem. Commun., 1989, 314-316.
Hisatome et al., "Porphyrins Coupled with Nucleoside Bases. Synthesis and Characterization of Adenine- and Thymine-Porphyrin Derivatives," Chemistry Letters, 1990, 2251-2254.
Hosseini et al., "Multiple Molecular Recognition and Catalysis. A Multifunctional Anion Receptor Bearing an Anion Binding Site, an Intercalating Group, and a Catalytic Site for Nucleotide Binding and Hydrolysis," J. Am. Chem. Soc., 1990, 112:3896-3904.
Hosseini et al., "Multiple Molecular Recognition and Catalysis. Nucleotide Binding and ATP Hydrolysis by a Receptor Molecule Bearing an Anion Binding Site, an Intercalator Group, and a Catalytic Site," J. Chem. Soc. Chem. Commun., 1988, 9:596-598.
Kimura et al., "A Study of New Bis(macrocyclic polyamine) Ligands as Inorganic and Organic Anion Receptors," J. Org. Chem., 1990, 55(1):46-48.
Kimura, "Macrocyclic Polyamines as Biological Cation and Anion Complexones--An Application to Calculi Dissolution," 113-141. 1990.
Kral et al., "Synthetic Sapphyrin-Cytosine Conjugates: Carriers for Selective Nucleotide Transport at Neutral pH," Journal of American Chemical Society, 1992, 114:8704-8705.
Li and Diederich, "Carriers for Liquid Membrane Transport of Nucleotide 5'-Triphosphates," J. Org. Chem. 1992, 47:3449-3454.
Marks and Stojakowvic, "Large Metal Ion-Centered Template Reactions. Chemical and Spectral Studies of the Superphthalocyanine Dioxocyclopentakis (1-iminoisoindolinato)uranium(VI) and Its Derivatives," J. Am. Chem. Soc., 1978, 1695-1705.
Rexhausen and Gossauer, "The Synthesis of a New 22 .pi.-Electron Macrocyle:Pentaphyrin," Che. Soc. Che. Commun., 1983, 6:275.
Schmidtchen, "A Non-Macrocyclic Host for Binding Organic Phosphates in Protic Solvents," Tetrahedron Letters, 1989, 30(34):4493-4496.
Seel and Vogtle, "Molecular Recognition and Transport of Nucleobases--Superiority of Macrobicyclid Host Molecules," Angew, Chem. Int. Ed. Engl., 1991, 30(4):442-444.
Sessler et al., "Anion Binding: A New Direction in Prophyrin-Related Research," Pure & Applied Chem., 65(3):393-398, 1993.
Sessler et al., "Cytosine Amine Derivatives," J. Org. Chem., 1992, 47:826-834.
Sessler et al., "Enhanced Transport of Fluoride Anion Effected Using Protonated Sapphyrin as a Carrier," J. Chem. Soc. Chem. Commun., 1991, 1732-1735.
Sessler et al., "In vitro photodynamic activity of diprotonated sapphyrin: a 22-.pi.-electron pentapyrrolic prophyrin-like macrocycle," Chemical Abstracts, 1990, 112:348-349, 112:194584t.
Sessler et al., "A water-stable gadolinium (III) complex derived from a new pentadentate expanded porphyrin ligand," Chemical Abstracts, 1989, 11:720, 11:125716e.
Sessler et al., "Synthetic and Structural Studies of Sapphyrin, a 22-.pi.-Electron Pentapyrrolic Expanded Porphyrin," J. Am. Chem. Soc., 1990, 112:2810-2813.
Sessler et al., "An Expanded Porphyrin: The Synthesis and Structure of a New Aromatic Pentadentate Ligand," J. Am. Chem. Soc., 1988, 110:5586-5588.
Shionoya et al., "Diprotonated Sapphyrin: A Fluoride Selective Halide Anion Receptor," Journal of the American Chemical Society, 1992, 114:5714-5722.
Tabushi et al., "Lipophilic Diammonium Cation Having a Rigid Structure Complementary to Pyrophosphate Dianions of Nucleotides. Selective Extraction and Transport of Nucleotides," J. Am. Chem. Soc., 1981, 103:6152-6157.
Tohda et al., "Liquid Membrane Electrode for Guanosine Nucleotides Using a Cytosine-Pendant Triamine Host as the Sensory Element," Analytical Chemistry, 1992, 64(8):960-964.

Affiliated with

Also associated with

Rating

Sapphyrin derivatives and conjugates does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Sapphyrin derivatives and conjugates, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Sapphyrin derivatives and conjugates will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-2311067