Saposin C-DOPS: a novel anti-tumor agent

Details Saposin C-DOPS: a novel anti-tumor agent Saposin C-DOPS: a novel anti-tumor agent

2004-03-16

2010-11-16

Helms, Larry R (Department: 1643)

Chemistry: natural resins or derivatives; peptides or proteins;

Proteins, i.e., more than 100 amino acid residues

C530S300000, C514S002600, C424S450000

Reexamination Certificate

active

07834147

ABSTRACT:
Compositions and methods for treating subjects with disorders characterized by hyper-proliferating cells such as tumors and cancers are provided. The compositions comprise agents that are combinations of saposin C (or prosaposin-related polypeptides) and dioleoylphosphatidylserine (or inner leaflet components). This anti-tumor agent is administered in the methods of the invention according to a dosing regimen. Administering an agent of the invention results in a positive therapeutic response in a subject with a tumor.

REFERENCES:
patent: 5700909 (1997-12-01), O'Brien
patent: 2001/0044131 (2001-11-01), Meyers
patent: 2002/0081698 (2002-06-01), Glucksmann
patent: 2002/0099001 (2002-07-01), Habberfield
patent: 2002/0177551 (2002-11-01), Terman
patent: 2003/0095999 (2003-05-01), Qi
patent: 2004/0120961 (2004-06-01), Koochekpour et al.
patent: WO 9503821 (1995-02-01), None
patent: WO 9833482 (1998-08-01), None
Bowie, et al. Science, vol. 247: 1306-1310, 1990.
Lazar, et al. Mol. Cell. Biol., 8(3): 1247-1252, 1988.
Burgess, et al. J. Cell Biol. 111: 2129-2138, 1990.
Ngo et al., in“The Protein Folding Problem and Tediary Structure Prediction”, 1994, Merz, et al. (ed.), Birkhauser, Boston, MA, pp. 433, and 492-495.
Skolnick et al., From genes to protein structure an function: novel applications of computational approaches in the genomic era, Trends in Biotech. 18: 34-39, 2000.
Morimoto et al., J. Bio. Chem., 1990, 265(4): 1933-1937.
Morimoto et al., Proc. Natl. Acad. Sci. U.S.A., 1989: 86: 3389-3393.
Vaccaro et al., FEBS 1993, 336(1): 159-162.
Egas et al., J. Biol. Chem. 2000, 275(49): 38190-38196.
Liepinsh et al., Nature Structural Biol., 1997, 4(10): 793-795.
Qi et al, Functional Human Saposins Expressed inEscherichia coli,J. Biol. Chem., Jul. 17, 1999, 269 (24):16746-16743, Amer. Soc. Biochem. Mol. Biol., Inc., U.S.A.
Vaccaro et al, Saposin C induces pH-dependent destabilization and fusion of phosphatidylserine-containing vesicles, FEBS Letters, 1994, 349:181-186, U.S.A.
Qi et al, Differential Membrane Interactions of Saposins A and C, J. Biol. Chem., Jul. 20, 2001, 276 (29):27010-27017, Amer. Soc. Biochem. Mol. Biol., Inc., U.S.A.
Luchette et al, Morphology of fast-tumbling bicelles: a small angle neutron scattering and NMR study, Biochim Biophys Acta, Aug. 2001, 1513(2):83-94, Elsevier Science B.V.
Nieh et al, SANS Study on the Effect of Lanthanide Ions and Charged Lipids on the Morphology of Phospholipid Mixtures, Biophysical J., 2002, 82:2487-2498, Biophy. Soc., USA.
Wang et al, Phospholipid vesicle fusion induced by saposin C, ABB, 2003, 415:43-53, Elsevier Science, USA.
Nieh et al, Concentration-Independent Spontaneously Forming Biomimetric Vesicles, Phys. Rev. Lett., 2003, 91(15):158105-1/4, Amer. Phys. Society, USA.
Nucleotide Sequence: BC001503.

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