Sampling system for containment and transfer of ions into a...

Radiant energy – Ionic separation or analysis – With plural – simultaneous ion generators

Reexamination Certificate

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C250S282000, C250S288000

Reexamination Certificate

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07928364

ABSTRACT:
The invention provides for efficient collection of analyte ions and neutral molecules from surfaces for their subsequent analysis with spectrometry. In an embodiment of the invention, a ‘multiple desorption ionization source’ includes a tube which can contain ions for subsequent sampling within a defined spatial resolution from desorption ionization at or near atmospheric pressures. In an embodiment, electrostatic fields are used to direct ions a plurality of tubes positioned in close proximity to the surface of the sample being analyzed. In an embodiment of the present invention, either narrow inside diameter capillary tubes or wide diameter tubes can be used in combination with a vacuum inlet to draw ions and neutrals into the spectrometer for analysis. In an embodiment of the invention, a dopant is introduced into a tube to analyze the sample. In an embodiment of the invention, a plurality of ionization sources is used to analyze the sample.

REFERENCES:
patent: 3633027 (1972-01-01), Ryhage
patent: 3957470 (1976-05-01), Dawes
patent: 4016421 (1977-04-01), Hull
patent: 4213326 (1980-07-01), Brodasky
patent: 4542293 (1985-09-01), Fenn
patent: 4546253 (1985-10-01), Tsuchiya
patent: 4654052 (1987-03-01), Sharp
patent: 4861988 (1989-08-01), Henion
patent: 5012052 (1991-04-01), Hayes
patent: 5055677 (1991-10-01), Amirav
patent: 5137553 (1992-08-01), Dawes
patent: 5192865 (1993-03-01), Zhu
patent: 5306412 (1994-04-01), Whitehouse
patent: 5352892 (1994-10-01), Mordehai
patent: 5367163 (1994-11-01), Otsuka
patent: 5381008 (1995-01-01), Tanner
patent: 5412208 (1995-05-01), Covey
patent: 5448062 (1995-09-01), Cooks
patent: 5552599 (1996-09-01), Giessmann
patent: 5559326 (1996-09-01), Goodley
patent: 5614711 (1997-03-01), Li
patent: 5624537 (1997-04-01), Turner
patent: 5684300 (1997-11-01), Taylor
patent: 5736741 (1998-04-01), Bertsch
patent: 5788166 (1998-08-01), Valaskovic
patent: 5868322 (1999-02-01), Loucks, Jr.
patent: 5959297 (1999-09-01), Weinberg
patent: 5997746 (1999-12-01), Valaskovic
patent: 6107628 (2000-08-01), Smith
patent: 6124675 (2000-09-01), Bertrand
patent: 6190559 (2001-02-01), Valaskovic
patent: 6225623 (2001-05-01), Turner
patent: 6359275 (2002-03-01), Bertsch
patent: 6395183 (2002-05-01), Valaskovic
patent: 6562211 (2003-05-01), Kunnecke
patent: 6583408 (2003-06-01), Smith
patent: 6600155 (2003-07-01), Andrien, Jr.
patent: 6646256 (2003-11-01), Gourley
patent: 6649907 (2003-11-01), Ebeling
patent: 6670608 (2003-12-01), Taylor
patent: 6690006 (2004-02-01), Valaskovic
patent: 6717139 (2004-04-01), Taniguchi
patent: 6723985 (2004-04-01), Schultz
patent: 6744041 (2004-06-01), Sheehan
patent: 6744046 (2004-06-01), Valaskovic
patent: 6784424 (2004-08-01), Willoughby
patent: 6803565 (2004-10-01), Smith
patent: 6806468 (2004-10-01), Laiko
patent: 6818889 (2004-11-01), Sheehan
patent: 6861647 (2005-03-01), Reilly
patent: 6878930 (2005-04-01), Willoughby
patent: 6888132 (2005-05-01), Sheehan
patent: 6914243 (2005-07-01), Sheehan
patent: 6943347 (2005-09-01), Willoughby
patent: 6949739 (2005-09-01), Franzen
patent: 6949740 (2005-09-01), Sheehan
patent: 6949741 (2005-09-01), Cody
patent: 6956205 (2005-10-01), Park
patent: 6977372 (2005-12-01), Valaskovic
patent: 6979816 (2005-12-01), Tang et al.
patent: 6992299 (2006-01-01), Lee
patent: 7015466 (2006-03-01), Takats
patent: 7064317 (2006-06-01), McLuckey
patent: 7081618 (2006-07-01), Laprade
patent: 7081621 (2006-07-01), Willoughby
patent: 7095019 (2006-08-01), Sheehan
patent: 7112785 (2006-09-01), Laramee
patent: 7138626 (2006-11-01), Karpetsky
patent: 7161145 (2007-01-01), Oser
patent: 7196525 (2007-03-01), Sparkman
patent: 7253406 (2007-08-01), Sheehan
patent: 7335897 (2008-02-01), Takats et al.
patent: 7423261 (2008-09-01), Truche
patent: 7429731 (2008-09-01), Karpetsky
patent: 7569812 (2009-08-01), Karpetsky
patent: 7700913 (2010-04-01), Musselman
patent: 7705297 (2010-04-01), Musselman
patent: 7714281 (2010-05-01), Musselman
patent: 7777181 (2010-08-01), Musselman
patent: 2002/0005478 (2002-01-01), Hillenkamp
patent: 2002/0121596 (2002-09-01), Laiko et al.
patent: 2002/0185593 (2002-12-01), Doring
patent: 2002/0185595 (2002-12-01), Smith
patent: 2002/0185606 (2002-12-01), Smith
patent: 2003/0052268 (2003-03-01), Doroshenko
patent: 2004/0094706 (2004-05-01), Covey
patent: 2004/0129876 (2004-07-01), Franzen
patent: 2004/0159784 (2004-08-01), Doroshenko
patent: 2005/0029442 (2005-02-01), Takats
patent: 2005/0079631 (2005-04-01), Laiko
patent: 2005/0230635 (2005-10-01), Takats
patent: 2005/0236565 (2005-10-01), Oser
patent: 2006/0071665 (2006-04-01), Blake
patent: 2006/0079002 (2006-04-01), Gologan
patent: 2006/0097157 (2006-05-01), Ouyang
patent: 2006/0163468 (2006-07-01), Wells
patent: 2006/0249671 (2006-11-01), Karpetsky
patent: 2006/0266941 (2006-11-01), Vestal
patent: 2007/0114389 (2007-05-01), Karpetsky
patent: 2007/0187589 (2007-08-01), Cooks
patent: 2008/0067348 (2008-03-01), Musselman
patent: 2008/0073548 (2008-03-01), Denton
patent: 2008/0156985 (2008-07-01), Venter
patent: 2008/0202915 (2008-08-01), Hieftje
patent: 2009/0272893 (2009-11-01), Hieftje
patent: 2263578 (1993-07-01), None
patent: WO03025973 (2003-03-01), None
patent: WO03081205 (2003-10-01), None
patent: WO2004068131 (2004-08-01), None
patent: WO2005094389 (2005-10-01), None
patent: WO 2007/103693 (2007-09-01), None
patent: WO 2007/140349 (2007-12-01), None
patent: WO2007/140351 (2007-12-01), None
patent: WO2008/046111 (2008-04-01), None
patent: WO 2008/054393 (2008-05-01), None
patent: WO2008/082603 (2008-07-01), None
patent: WO 2009/023361 (2009-02-01), None
Barber, M. et al., “Fast atom bombardment of solids (F.A.B.): a new ion source for mass spectrometry” J.Chem. Soc. Chem. Commun., 1981, 325.
Cody, R.B. et al., “Versatile New Ion Source for the Analysis of Materials in Open Air under Ambient Conditions” Anal. Chem., 2005, 77, 2297-2302.
Cooks, R.G. et al., “Ambient Mass Spectrometry”, Science, 2006, 311, 1566-1570.
Dalton, C.N. et al., “Electrospray-Atmospheric Sampling Glow Discharge Ionization Source for the Direct Analysis of Liquid Samples”, Analytical Chemistry, Apr. 1, 2003, vol. 75, No. 7, pp. 1620-1627.
Fenn et al., “Electrospray Ionization for Mass Spectrometry of Large Biomolecules,” Science, vol. 246, No. 4926, Oct. 6, 1989, pp. 64-71.
Guzowski, J.P. Jr. et al., “Development of a Direct Current Gas Sampling Glow Discharge Ionization Source for the Time-of-Flight Mass Spectrometer”, J. Anal. At. Spectrom., 14, 1999, pp. 1121-1127.
Hill, C.A. et al., “A pulsed corona discharge switchable high resolution ion mobility spectrometer-mass spectrometer”, Analyst, 2003, 128, pp. 55-60.
Hiraoka, K. et al., “Atmospheric-Pressure Penning Ionization Mass Spectrometry”, Rapid Commun. Mass Spectrom., 18, 2004, pp. 2323-2330.
Karas, M. et al., “Laser desorption ionization of proteins with molecular masses exceeding 10,000 daltons” Anal. Chem. 1988, 60, 2299-2301.
Kojiro, D.R. et al., “Determination of C.sub.1-C.sub.4 Alkanes by Ion Mobility Spectrometry”, Anal. Chem., 63, 1991, pp. 2295-2300.
Leymarie, N. et al., “Negative Ion Generation Using a MAB Source”, presented at the Annual Meeting of the American Society of Mass Spectrometry, 2000.
McLuckey, S.A. et al., “Atmospheric Sampling Glow Discharge Ionization Source for the Determination of Trace Organic Compounds in Ambient Air”, Anal. Chem., 60, 1988, pp. 2220-2227.
Otsuka, K. et al., “An Interface for Liquid Chromatograph/Liquid Ionization Mass Spectrometer”, Analytical Sciences, Oct. 1988, vol. 4, pp. 467-472.
Tanaka, K. et al., “Protein and polymer analyses up to m/z 100,000 by laser ionization time-of-flight”, Rapid Commun. Mass Spectrom., 1988, 2, 151-153.
Takáts et al., “Mass Spectrometry Sampling Under Ambient Conditions with Desorption Electrospray Ionization,”Science, vol. 306, No. 5695, Oct. 15, 2004, pp. 471-473.
Zhao, J. et al., Liquid Sample Injection Using an

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