Measuring and testing – Volume or rate of flow – Using differential pressure
Reexamination Certificate
2007-05-08
2007-05-08
Thompson, Jewel (Department: 2855)
Measuring and testing
Volume or rate of flow
Using differential pressure
Reexamination Certificate
active
11016310
ABSTRACT:
An apparatus that couples automated injection with flow feedback to provide nanoliter accuracy in controlling microliter volumes. The apparatus comprises generally a source of hydraulic fluid pressure, a fluid isolator joined to the outlet of the hydraulic pressure source and a flow sensor to provide pressure-driven analyte metering. For operation generally and particularly in microfluidic systems the hydraulic pressure source is typically an electrokinetic (EK) pump that incorporates gasless electrodes. The apparatus is capable of metering sub-microliter volumes at flowrates of 1–100 μL/min into microsystem load pressures of up to 1000–50 psi, respectively. Flowrates can be specified within 0.5 μL/min and volumes as small as 80 nL can be metered.
REFERENCES:
patent: 4656448 (1987-04-01), Luetzow
patent: 6224728 (2001-05-01), Oborny et al.
patent: 6725731 (2004-04-01), Wiklund et al.
Crocker Robert W.
Harnett Cindy K.
Mosier Bruce P.
Patel Kamlesh D.
Nissen Donald A.
Sandia National Laboratories
Thompson Jewel
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