Sample mounts for microcrystal crystallography

Details Sample mounts for microcrystal crystallography Sample mounts for microcrystal crystallography

2007-08-28

2007-08-28

Davis, Robert B. (Department: 1722)

X-ray or gamma ray systems or devices

Specific application

Diffraction, reflection, or scattering analysis

C378S071000, C378S073000, C378S074000, C378S069000, C378S080000, C378S081000, C378S205000, C378S206000, C378S208000, C378S068000, C269S047000, C269S287000, C269S900000, C269S908000, C269S909000, C250S440110, C250S442110, C250S491100, C029S281100

Reexamination Certificate

active

11228455

ABSTRACT:
Sample mounts (10) for mounting microcrystals of biological macromolecules for X-ray crystallography are prepared by using patterned thin polyimide films (12) that have curvature imparted thereto, for example, by being attached to a curved outer surface of a small metal rod (16). The patterned film (12) preferably includes a tapered tip end (24) for holding a crystal. Preferably, a small sample aperture is disposed in the film for reception of the crystal. A second, larger aperture can also be provided that is connected to the sample aperture by a drainage channel, allowing removal of excess liquid and easier manipulation in viscous solutions. The curvature imparted to the film (12) increases the film's rigidity and allows a convenient scoop-like action for retrieving crystals. The polyimide contributes minimally to background and absorption, and can be treated to obtain desired hydrophobicity or hydrophilicity.

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