Measuring and testing – Sampler – sample handling – etc. – With constituent separation
Reexamination Certificate
2005-06-20
2009-08-25
Griffin, Walter D (Department: 1797)
Measuring and testing
Sampler, sample handling, etc.
With constituent separation
Reexamination Certificate
active
07578206
ABSTRACT:
A method and system to deposit rapidly, accurately and efficiently liquid droplets onto a sample plate. A liquid from which the droplet is formed contains sample molecules, matrix molecules or a mixture of both sample and matrix molecules. A sample plate is positioned with respect to a position below a portion of the liquid, such as a droplet. A power supply forms an electric field between the sample plate and the liquid, which pulls the droplet to a target location on the sample plate. A plurality of capillary columns is provided for simultaneous or successive multiple depositions via application of one or more high voltage pulses between the liquid sample array and a sample plate.
REFERENCES:
patent: 3476291 (1969-11-01), Glaser
patent: 3661304 (1972-05-01), Martinez et al.
patent: 3941312 (1976-03-01), Ohno
patent: 4867947 (1989-09-01), Andresen et al.
patent: 5045172 (1991-09-01), Guzman
patent: 5232565 (1993-08-01), Zare et al.
patent: 5630925 (1997-05-01), Pentoney et al.
patent: 5750015 (1998-05-01), Soane et al.
patent: 5776359 (1998-07-01), Schultz et al.
patent: 5879949 (1999-03-01), Cole et al.
patent: 5916524 (1999-06-01), Tisone
patent: 5958203 (1999-09-01), Parce et al.
patent: 5969350 (1999-10-01), Kerley et al.
patent: 5972187 (1999-10-01), Parce et al.
patent: 6040193 (2000-03-01), Winkler et al.
patent: 6080295 (2000-06-01), Parce et al.
patent: 6093296 (2000-07-01), Soane et al.
patent: 6103199 (2000-08-01), Bjornson et al.
patent: 6132582 (2000-10-01), King et al.
patent: 6132685 (2000-10-01), Kercso et al.
patent: 6149787 (2000-11-01), Chow et al.
patent: 6149815 (2000-11-01), Sauter
patent: 6191418 (2001-02-01), Hindsgaul et al.
patent: 6231739 (2001-05-01), Nordman et al.
patent: 6350617 (2002-02-01), Hindsgaul et al.
patent: 6657191 (2003-12-01), Park
patent: 6918309 (2005-07-01), Brock et al.
patent: 2001/0049148 (2001-12-01), Wolk et al.
patent: 2002/0003177 (2002-01-01), O'Connor
patent: 2004/0227072 (2004-11-01), Park
patent: 4229005 (1994-03-01), None
patent: 19503634 (1995-10-01), None
patent: 24230 (1981-02-01), None
patent: 2332273 (1999-06-01), None
patent: 9701085 (1997-01-01), None
patent: 1999029497 (1999-06-01), None
Schuerenberg, “Prestructured MALDI-MS Sample Supports,” Anal. Chem. 72: 3436-3442 (2000).
Onnerfjord, “Picoliter Sample Preparation in MALDI-TOF MS Using a Micromachined Silicon Flow-Through Dispenser,” Anal. Chem. 70: 4755-4760 (1998).
Preisler, “On-Line MALDI-TOF MS Using a Continuous Vacuum Deposition Interface,” Anal. Chem. 70: 5278-5287.
Laurell, “Silicon Microstructures for High-Speed and High-Sensitivity Protein Identifications,” J of Chromatography B. 752: 217-232 (2001).
Miliotis, “Protein Identification Platform Utilizing Micro Dispensing Technology Interfaced to Matrix-Assisted Laser Desorption Ionization Time-of-Flight Mass Spectrometry,” J of Mass Spectrom. 35: 369-377 (2000).
Flight Mass Spectrometry Using an On-Line Coupled Piezoelectric Flow-Through Microdispenser, J of Mass Spectrom. 35: 369-377 (2000).
Laurell, “Proteomics-Protein Profiling Technology:The Trend Towards a Microfabricated Toolbox Concept,” Trends in Analytical Chemistry. 20:225-231 (2001).
Yogi, “On-Demand Droplet Spotter for Preparing Pico-to-Femtoliter Droplets on Surfaces,” Anal. Chem. 72:1896-1902 (2001).
DeVault, “Electrofilament Deposition and Off-Column Detection of Analytes Seperated by Capillary Electrophoresis,” Electrophoresis. 21:1320-1328 (2000).
Preisler, “Capillary Electrophoresis-Matrix-Assisted Laser Desorption/Ionization Time-of-Flight Mass Spectrometry Using a Vacuum Deposition Interface,” Anal. Chem. 72:4785-4795 (Oct. 2000).
Hager, “Droplet Electrospray Mass Spectrometry,” Anal. Chem. 66:3944-3949 (1994).
Ojima, “Droplet Electrocoupling Between Capillary Electrophoresis and Matrix Assisted Laser Desorption/Ionization-Time of Flight-Mass Spectroscopy and its Application,” Electrophoresis 22: 3478-3482 (2001).
Miliotis, “Development of Silicon Microstructures and Thin-Film MALDI Target Plates for Automated Proteomics Sample Identification,” J of Neuroscience Methods. 109:41-46 (2001).
Laurell, “Microfluidic Components for Protein Characterization,” Reviews in Molecular Biotechnology. 82:161-175 (2001).
Marko-Varga, “Disposable Polymeric High-Density Nanovial Arrays for Matrix Assisted Laser Desorption/Ionization-Time of Flight-Mass Spectrometry:I. Microstructure Development and Manufacturing,” Electrophoresis: 22: 3978-3983 (2001).
Miliotis, “Ready-Made Matrix-Assisted Laser Desorption/Ionization Target Plates Coated with Thin Matrix Layer for Automated Sample Deposition in High-Density Array Format,” Rapid Commun. Mass Spectrom. 16: 117-126 (2002).
Ekstrom, “Signal Amplification Using “Spot-on-a-Chip” Technology for the Identification of Proteins via MALDI-TOF MS,” Anal. Chem. 73:214-219 (2001).
Ericsson, “Downsizing Proteolytic Digestion and Analysis Using Dispenser-Aided Sample Handling and Nanovial Matrix-Assisted Laser/Desorption Ionization-Target Arrays,” Proteomics 1: 1072-1081 (2001).
Ekstrom, “Disposable Polymeric High-Density Nanovial Arrays for Matrix Assisted Laser Desorption/Ionization-Time of Flight-Mass Spectrometry: II. Biological Application,” Electrophoresis 22: 3984-3992 (2001).
Morozov, “Electrospray Deposition as a Method for Mass Fabrication of Mono-and Multicomponent Microarrays of Biological and Biologically Active Substances,” Anal. Chem. 71:311 (Aug. 1999).
Lemmo, “Characterization of an Inkjet Chemical Microdispenser for Combinatorial Library Synthesis,” Anal. Chem. 69:543-551 (1997).
Miliotis, “Analysis of Regulatory Phosphorylation Sites in ZAP-70 by Capillary High-Performance Liquid Chromatography Coupled to Electrospray Ionization or Matrix-Assisted Laser Desorption Ionization . . . .” J. Chromatography B, 752: 323-334 (2001).
Ekstrom, “Integrated Microanalytical Technology Enabling Rapid and Automated Protein Identification,” Anal. Chem. 72:286-293 (2000).
Onnerfjord, “Homogeneous Sample Preparation for Automated High Throughput Analysis with Matrix-Assisted Laser Desorption/Ionisation Time-of-Flight Mass Spectrometry,” Rapid Commun. Mass Spectrom. 13: 315-322 (1999).
Miliotis, “Capillary Liquid Chromatography Interfaced to Matrix-Assisted laser Desorption/Ionization Time-of-Flight Mass Spectromtery,” J. Mass. Spectrom. 35: 369-377 (2000).
Johnson, “A CE-MALDI Interface Based on the Use of Prestructured Sample Supports,” Anal. Chem. 73: 1670-1675 (Apr. 2001).
Brock Ansgar
Downs Robert C
Shaw Christopher M.
Genomics Institute of the Novartis Research Foundation
Griffin Walter D
IRM LLC
Ramdhanie Bobby
Smith Timothy L.
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