Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving viable micro-organism
Patent
1999-10-07
2000-10-31
Leary, Louise N.
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving viable micro-organism
435 31, 4352831, 4352871, 4352874, C12Q 104, C12Q 122
Patent
active
06140070&
ABSTRACT:
The present invention is directed to methods and apparatus for collecting and pooling the contents of a multiple number of individual sample containers, the apparatus comprising an autoclavable collection bottle capped with a closure-adaptor means having at least one passageway for transfering the fluid contents of the sample containers into the collection bottle. In one embodiment of the invention, the closure-adaptor means comprises a plastic retainer ring for securely holding a flanged cylindrical stopper in which the above-mentioned passageway is formed. Still another aspect of the invention relates to a method of sample testing comprising collecting a pooled sample of a solution or gel, inoculating and/or filtering the pooled sample, and analyzing the inoculated sample or the filter retentate for microbial contamination. For instance, the present method may be used for carrying out either filtered membrane sterility testing or direct transfer preservative efficacy testing of a health care or pharmaceutical product.
REFERENCES:
patent: 4025306 (1977-05-01), Studer
patent: 4036698 (1977-07-01), Bush et al.
patent: 4829005 (1989-05-01), Friedman et al.
patent: 5998219 (1999-12-01), Costanzo et al.
Baritot Richard
Costanzo Stephen
Bausch & Lomb Incorporated
Leary Louise N.
Thomas John E.
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