Sample analysis system with chip-based electrophoresis device

Details Sample analysis system with chip-based electrophoresis device Sample analysis system with chip-based electrophoresis device

2005-09-13

2005-09-13

Choi, Ling-Sui (Department: 1713)

Chemistry: electrical and wave energy

Apparatus

Electrophoretic or electro-osmotic apparatus

C204S601000, C204S600000, C204S453000, C204S451000, C204S450000

Reexamination Certificate

active

06942777

ABSTRACT:
The present invention relates to a sample analysis system with chip-based electrophoresis device, particularly, the chip electrophoresis is connected to the dynamic flow-based auto-sampling device to introduce the sample into the chip-based electrophoresis device. By utilizing the derivatization biochemistry method to have a surface modification on the sample loading channel, it prevents the sample from being adhered to the wall of the sample loading channel, and hence increases the sample loading rate, reduces cross-contamination of samples and performs specific bio-reaction by using the immobilization of matter including antigen, antibody, protein, or enzyme. This invention makes use of the continuous split flow and electric voltage control to work with the detecting unit, signal collecting unit, and signal processing unit so that the sample undergoes a timely, fast, continuous analysis without having interference from the sample of other time.

REFERENCES:
patent: 4415428 (1983-11-01), Nochumson et al.
patent: 6013168 (2000-01-01), Arai
Chiem et al., Microchip-based capillary electrophoresis for immunoassays: analysis of monoclonal antibodies and theophylline Anal. Chem., 69, 373-378 (1997).
Chiem et al., “Microchip systems for immunoassay: an integrated immunoreactor with electrophoretic separation for serum theophylline determination”, Clinical Chemistry, 44(3), 591-598(1998).
Seiler et al., “Planar glass chips for electrophoresis: repetitive sample injection, quantitation, and separation efficiency”, Anal. Chem., 65, n1481-1488(1993).
Seiler et al., Electroosmotic pumping and valveless control of fluid flow within a manifold of capillaries on a glass chip, Anal. Chem., 66, 3485-3491(1994).
Jacobson et al., “Fused quartz substrates for microchip electrophoresis”, Anal. Chem., 67, 2059-2063(1995).

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