Sampangine and derivatives useful as an antifungal agent

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

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514288, 546 66, 546 49, A61K 3147, C07D22118

Patent

active

051283441

ABSTRACT:
A new compound 3-Methoxysampangine and its analogs, compositions thereof, and method of using as an antifungal agent particularly effective against Candida albicans, Cryptococcus neoformans, and Aspergillus fumigatus.

REFERENCES:
patent: 4080456 (1978-03-01), Seidelmann et al.
patent: 4965272 (1990-10-01), Hufford et al.
Liu, S. et al, "3-Methoxysampangine, a novel antifungal copyrine alkaloid, etc.", CA 113, 37723v (Jul. 1990).
Liu et al, Antimicrobial Agents and Chemotherapy, Apr. 1990, pp. 529-533.
Hufford et al, Journal of Natural Products, vol. 50, No. 5 (1987) pp. 961-964.

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