Salts of ranitidine and complexes of bismuth with carboxylic aci

Details Salts of ranitidine and complexes of bismuth with carboxylic aci Salts of ranitidine and complexes of bismuth with carboxylic aci

1989-07-17

1991-04-16

Raymond, Richard L.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

549206, 549495, C07F 994, C07D30752, C07D30754

Patent

active

050082566

ABSTRACT:
The invention relates to salts formed between ranitidine and a complex of bismuth with a carboxylic acid, and solvates of such salts. Examples of suitable carboxylic acids are citric acid, tartaric acid and agaricic acid.
The salts are useful in the treatment of gastrointestinal disorders, particularly gastroduodenal conditions. The salts show the antisecretory activity associated with ranitidine together with antibacterial activity against Campylobacter pylori and they also possess cytoprotective properties.

REFERENCES:
patent: 4128658 (1978-12-01), Price et al.
Ward et al., Proc. Adelaide, 1979, A30. (abstract).
Bianchi Porro et al., Scandinavian Journal of Gastroenterology, 21, Supplement 122, 1986, 39-41.
Lam et al., Gut, 1984, 703-706.
Salmon, P. R., Digestion, 1987, 37 (suppl. 2), 42-46.
British Pharmaceutical Codex, 1949, "Bismuthi Carbonas", 150-154 and 1183-1185.
S. J. Konturek et al., Gut, 1987, 28, pp. 1557-1563.
S. J. Konturek et al., Scandinavian Journal of Gastroenterology, 1987, 22, pp. 1059-1063.
R. Iserhard et al., Abstract of a paper given at the 20th Congress of the European Assoc. of Gastroenterology and Endoscopy, Apr. 28-30, 1988.
Lancet (M. Guslandi, 1988, 1(8599), pp. 1383-1385).
M. V. Borkent et al., Gut, 1988, 29, pp. 385-389.

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