Salts of peptides with carboxy-terminated polyesters

Details Salts of peptides with carboxy-terminated polyesters Salts of peptides with carboxy-terminated polyesters

1999-01-22

2000-03-07

Nutter, Nathan M.

Synthetic resins or natural rubbers -- part of the class 520 ser

Synthetic resins

Mixing of two or more solid polymers; mixing of solid...

514 2, 5147723, 5147726, 514800, 514806, 514807, 514808, 514809, 514963, 424489, 424492, 424499, 435180, 435181, 435182, 42840234, A61K 916, A61K 952, A61K 3702, B32B 516

Patent

active

060341750

ABSTRACT:
This invention relates to novel salts composed of a cation derived from a peptide containing at least one basic group and an anion derived from a carboxy-terminated polyester, processes for the manufacture of such salts, and the use of such salts in the manufacture of extended release pharmaceutical compositions. The salts of the invention possess a variety of properties which are useful in the formulation of extended release pharmaceutical compositions, whether the salts are in pure form or are in admixture with either an excess of the peptide in its free, unbound form or an excess of the free polyester.

REFERENCES:
patent: 4675189 (1987-06-01), Kent et al.
patent: 4767628 (1988-08-01), Hutchinson
patent: 4938763 (1990-07-01), Dunn et al.
patent: 4997643 (1991-03-01), Partain, III et al.
patent: 5005602 (1991-04-01), Hutchinson
patent: 5672659 (1997-09-01), Shalaby et al.
patent: 5889110 (1999-03-01), Hutchinson
F. G. Hutchinson et al., "Biodegradable Polymers for the Delivery of Polypeptides and Proteins", Ziekenhuisfarmacie, vol. 4, No. 2, 1988, pp. 54-56.
Lawter et al, Proc. Int. Symp. Control. Rel. Bioact. Mater., 14 (1987), pp. 99-100.
Okada et al., Pharmaceutical Research, 8 (5), 1991, p. 587.

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