Salts of erythromycin A esters

Details Salts of erythromycin A esters Salts of erythromycin A esters

1980-02-20

1981-04-28

Brown, Johnnie R.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

424180, C07H 1708

Patent

active

042647657

ABSTRACT:
Highly water-soluble erythromycin A derivatives wherein the desosamine moiety is quaternized with an acyloxy-, benzoyloxy- or alkoxycarbonyl-(or carboxy)-acylmethyl iodide, bromine or chloride and esterified in the 2-position with loweralkyl or --(CH.sub.2).sub.n CO.sub.2 R", wherein R" is H, loweralkyl or substituted loweralkyl and n is an integer from 1-5. These new esters readily convert to erythromycin A upon administration to warm-blooded animals.

REFERENCES:
patent: 2857312 (1958-10-01), Stephens
patent: 2881163 (1959-04-01), Walasek
patent: 3558594 (1971-01-01), Jones et al.
Stephens, "Antibiotic Annual", 1953-1954, pp. 514-521.
Noller, "Chem. of Organic Compounds", 3rd Ed., W. B. Saunders Co., 1965, p. 253.

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