Salts of asiatic and madecassic acid suitable for the...

Organic compounds -- part of the class 532-570 series – Organic compounds – Carboxylic acids and salts thereof

Reexamination Certificate

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C424S400000, C424S401000, C424S443000, C552S284000

Reexamination Certificate

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06891063

ABSTRACT:
Salts of asiatic and madecassic acid with pharmaceutically acceptable organic bases, suitable for the preparation of pharmaceutical and cosmetic compositions for the topical and systemic treatment of erithema, varicose ulcers, venous insufficiency, bedsores, delayed cicatrization, ambustions, traumatic and surgery wounds, alloeosises of the cutaneous trophism, ophthalmic alloeosises and inflammatory processes.

REFERENCES:
patent: 3366669 (1968-01-01), Ratsimamanga
patent: 4393048 (1983-07-01), Mason et al.
patent: WO9823574 (1998-06-01), None
F. Bonte et al.Influence of Asiatic Acid, Madecassic Acid, and Asiaticoside on Human Collagen I Synthesis. Planta. Med. vol. 60, 1994, pp. 133-135.
Francois-Xavier Maquart et al.Stimulation of Collagen Synthesis in Fibroblast Cultures by a Triterpene Extracted From Centella asiatica. Connective Tissue Research, vol. 24, 1990, pp. 107-120.
Pil-Jong Shim et al.Asiaticoside Mimetics As Wound Healing Agent. Bioorganic & Medicinal Chemistry Letters, vol. 6, No. 24, 1996, pp. 2937-2940.

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