Salts/ion pairs of non-steroidal anti-inflammatory drugs in vari

Details Salts/ion pairs of non-steroidal anti-inflammatory drugs in vari Salts/ion pairs of non-steroidal anti-inflammatory drugs in vari

1993-06-15

1995-01-31

Cintins, Marianne M.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Radical -xh acid, or anhydride, acid halide or salt thereof...

514569, 514570, 514653, 514159, A61K 31195

Patent

active

053859413

ABSTRACT:
Novel pharmaceutical compositions are comprised of the salt or ion pair formation of a non-steroidal anti-inflammatory drug and an antihistamine or other decongestant. The physico-chemical characteristics of these compositions show them to be substantially different from their parent acid or base and will enable the preparation of dual action sustained or enhanced relief therapy regimens. The compositions also possessed enhanced stability and therefore the multi-symptom relief can be incorporated into a number of dosage forms such as capsules, tablets, elixirs, ointments and the like.

REFERENCES:
patent: 4990535 (1991-02-01), Cho et al.
patent: 5025019 (1991-06-01), Sunshine et al.
patent: 5075114 (1991-12-01), Roche
patent: 5215755 (1993-06-01), Roche et al.
patent: 5296233 (1994-03-01), Batista et al.

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