Organic compounds -- part of the class 532-570 series – Organic compounds – Heterocyclic carbon compounds containing a hetero ring...
Reexamination Certificate
2009-07-14
2011-11-22
Young, Shawquia (Department: 1626)
Organic compounds -- part of the class 532-570 series
Organic compounds
Heterocyclic carbon compounds containing a hetero ring...
Reexamination Certificate
active
08063227
ABSTRACT:
Disclosed herein are new salts and polymorphs of desazadesferrithiocin polyether (DADFT-PE) analogues, as well as pharmaceutical compositions comprising them and their application as metal chelation agents for the treatment of disease. Methods of chelation of iron and other metals in a human or animal subject are also provided for the treatment of metal overload and toxicity.
REFERENCES:
patent: 2005/0101782 (2005-05-01), Krich
patent: 2006/0069134 (2006-03-01), Maruoka
patent: 2008/0138440 (2008-06-01), Swaminathan et al.
patent: 2005023310 (2005-03-01), None
patent: 2005023310 (2005-03-01), None
patent: 2006107626 (2006-10-01), None
patent: 2008115433 (2008-09-01), None
patent: 2008130395 (2008-10-01), None
patent: 2008130395 (2008-10-01), None
Byrn, et al. ed. “Comparing X-ray Powder Data”. Solid State Chemistry of Drugs, 2ndedition, p. 63.
Bergeron, RJ, Iron chelation promoted by desazadesferrithiocin analogs: An enantioselective barrier, Chirality; vol. 15, Issue 7, pp. 593-599, 2003.
Bergeron, RJ, et al, Design, Synthesis, and Testing of Non-Nephrotoxic Desazadesferrithiocin Polyether Analogues, J. Med. Chem. 2008, 51, 3913-3923.
Bergeron, RJ, et al, Polyamine-Vectored Iron Chelators: The Role of Charge, J. Med. Chem. 2005, 48, 4120-4137.
Bergeron, RJ, et al, (S)-4,5-Dihydro-2-(2-hydroxy-4-hydroxyphenyl)-4-methyl-4-thiazolecarboxylic Acid Polyethers: A Solution to Nephrotoxicity, J. Med. Chem. 2006, 49, 2772-2783.
Bergeron, RJ, et al, Impact of the 3,6,9-Trioxadecyloxy Group on Desazadesferrithiocin Analogue Iron Clearance and Organ Distribution, J. Med. Chem. 2007, 50, 3302-3313.
“EP08742093 EP Search Report and Opinion”,University of Florida, USA, Dec. 27, 2010.
Bergeron, RJ; Biometals, Nov. 2010; (e-publication only) http://www.springerlink.com/content/p5254pq117818l12/, Nov. 20, 2010.
WO 2008115433; ISR and WO, University of Florida, USA, Jun. 19, 2008.
WO2010009120 IPRP, FerroKin (FKB0001-401), Jan. 27, 2011.
Andres Patricia
Hanko Jason A.
Parent Stephan D.
Rienhoff, Jr. Hugh Y.
Tapper Amy E.
Bennett Dennis A.
Ferrokin Biosciences, Inc.
Hathaway Cynthia
Young Shawquia
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