Salts and polymorphs of a VEGF-R inhibitor

Organic compounds -- part of the class 532-570 series – Organic compounds – Four or more ring nitrogens in the bicyclo ring system

Reexamination Certificate

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Reexamination Certificate

active

07928226

ABSTRACT:
The invention relates to salts and free base forms of N,2-dimethyl-6-[7-(2-morpholinoethoxy)quinolin-4-yloxy]benzofuran-3-carboxamide. The invention further relates to pharmaceutical compositions of these salts and free base forms and methods of treating disorders such as cancer using such compositions.

REFERENCES:
patent: 7381824 (2008-06-01), Hong et al.
patent: 2005/0137395 (2005-06-01), Hong et al.
patent: WO00/18761 (2000-04-01), None
patent: WO01/74360 (2001-10-01), None
patent: WO02/12226 (2002-02-01), None
patent: WO03/074529 (2003-09-01), None
patent: WO2005/063739 (2005-07-01), None
patent: WO2007/017740 (2007-02-01), None
patent: WO2007/006618 (2007-10-01), None
Berge et al Journal of Pharmaceutical Sciences, vol. 66(1) (1977) pp. 1-19.
Berge, S. et al., “Pharmaceutical Salts,”Journal of Pharmaceutical Sciences, vol. 66, No. 1, Jan. 1977, 1-19.
Corrigan, O., “Salt Forms: Pharmaceutical Aspects,”Encyclopedia of Pharmaceutical Technology, 2006, 1:1, 3177-3187, Third Edition, Trinity College, University of Dublin, Dublin, Ireland.

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