Salts and mixtures of hyaluronic acid with pharmaceutically acti

Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives

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514 54, 514420, 514576, 514777, 514912, 424 7805, C07H 504

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active

054420539

ABSTRACT:
Two pharmaceutically useful fractions of hyaluronic acid are obtained comprising a first fraction with a molecular weight between 50,000 and 100,000 which is useful for wound healing, and a second fraction having a molecular weight between 500,000 and 730,000 which is useful for intraocular and intraarticular injections.
In addition, pharmaceutical preparations for topical administration are provided containing a pharmacologically active substance together with hyaluronic acid or a molecular weight fraction thereof. The hyaluronic acid may be in the form of the free acid or may be a salt with an alkali or alkaline earth metal, magnesium, aluminum or ammonium, or in the form of a salt with one or more pharmacologically active substances.

REFERENCES:
patent: 2583096 (1952-07-01), Hadidian et al.
patent: 3396081 (1968-08-01), Billek
patent: 3436454 (1969-04-01), Nouvel
patent: 3792164 (1974-02-01), Bechtold
patent: 3845201 (1974-10-01), Haddad et al.
patent: 3870791 (1975-03-01), Haddad et al.
patent: 3887703 (1975-06-01), Manoussos et al.
patent: 4003991 (1977-01-01), Krohn et al.
patent: 4045558 (1977-08-01), Smith et al.
patent: 4061722 (1977-12-01), Bodor
patent: 4141973 (1979-02-01), Balazs
patent: 4255415 (1981-03-01), Chrai et al.
patent: 4271143 (1981-06-01), Schoenwald et al.
patent: 4272522 (1981-06-01), Balazs
patent: 4303676 (1981-12-01), Balazs
patent: 4328803 (1982-05-01), Pape
patent: 4500676 (1985-02-01), Balazs et al.
patent: 4517295 (1985-05-01), Bracke et al.
patent: 4593091 (1986-06-01), della Valle et al.
patent: 4851521 (1989-07-01), della Valle et al.
patent: 5166331 (1992-11-01), della Valle et al.
patent: 5202431 (1993-04-01), della Valle et al.
Deguchi et al "Binding of Aminoglycoside Antibiotics to Acidic Mucopolysaccharides", Journal of Antibiotics, Feb. 1978, vol. 31, pp. 150-155.
M. Walther, Minerva Gynecologica, 33, 497-499 (1981).
P. Surtoli et al., Giornale Italiano di Dermatologia, 45(8), 468-471 (1970).
R. O. Cravioto et al., Science, 111, 520-521 (1950).
E. A. Balazs, Chemistry and Molecular Biology of the Intercellular Matrix, III, 1241-1253 (1970).
N. W. Rydell et al., Clinical Orthopaedics and Related Research, 80, 25-32 (1971).
W. McIlwraith, Journal of the American Veterinary Medical Association, 239-250 (1982).
S. P. Vilesov et al., Klin Khir, 9, p. 71 (1970).
Nizolek et al., The Cornell Veterinarian, 71(4) 355-375 (1981).
Weirich et al., Dermatologica, 152(2) 87-99 (1976).
The New Encyclopaedia Britannica, vol. VIII, 1977:102.
Mizushima, Nippon Rinsho, 26(1) 61-65 (1968).
Katsu et al., Nippon Rinsho, 26(1) 89-95 (1968).
Vasil'ev et al., Antibiotiki, 21(3):238-242 (1976).
Shchekotova, Antibiotiki, 17(2) 134-137 (1982).
Haydon, Klin Monatsbl. Augenheilkd, 183(3):213-215 (1983).
Stavri et al., Rev. Med. Chir. Soc. Med. Nat. Iasi., 81(1):133-136 (1981).
Leibowitz et al., Curr. Eye Res. 1(5)259-266 (1981).
Darougar et al., Br. J. Ophthalmol. 64(1):37-42 (1980).
Genee et al., Ophthalmologica, 184(2) 92-96 (1982).
Sakaguchi et al., Nippon Ganka Kiyo, 20(7):743-746 (1969).
McGuinness, Med. J. Aust., 140(6):383 (1984).
Nakatsue, Nippon Ganka Gakkai Zasshi 75(5):1244-1247 (1971).
Norn, Ugeskr. Laeger, 137(42):2458-2460 (1975).
Nielson et al., Acta Ophthalmol., 57(3):418-424 (1979).
Fisher et al., J. Infect. Dis., 147(1):164 (1983).
Bird et al., Br. J. Ophthalmol., 64(3):191-200 (1980).
Tabbara et al., Am. J. Ophthalmol., 98(3):378-380 (1984).
Hung et al., Br. J. Ophthalmol., 68(3):192-195 (1984).
Kabuni et al., Bull. Soc. Belge. Ophtalmol., 201:99-104 (1982).
Szasne Zacsko et al., Acta. Pharm. Hung., 53(4):150-153 (1983).
Brian et al., J. Pharm. Sci., 63(4):633-635 (1974).
Springer et al., Pharmazie, 36(10):706-708 (1981).
Salminen et al., Exp. Eye Res., 38(2):203-206 (1984).
Merte et al., Klin. Monatsbl. Augenheilkd 184(3):227-232 (1984).
Schmitz et al., Fortschr. Ophthalmol., 79(4):374-378 (1982).
Dhir et al., Indian J. Ophthalmol., 29(3):229-233 (1981).
Nielsen, Acta Ophthalmol., 59(4):495-502 (1981).
Bonomi et al., Albrecht Von Graefes Arch. Klin. Exp. Ophthalmol., 217(3):175-181 (1981).
Ichigashira et al., Steroids, 32(5) 615-628 (1978).
Egorov et al., Oftalmol. Zh., 35(4) 212-215 (1980).
Niebroj et al., Klin. Oczna, 46(3) 301-303 (1976).
M. Walther, Minerva Gynecologica, 33, 497-499 (1981).
P. Surtoli et al., Giornale Italiano di Dermatologia, 45(8), 468-471 (1970).
R. O. Cravioto et al., Science, 111, 520-521 (1950).
E. A. Balazs, Chemistry and Molecular Biology of the Intercellular Matrix, III, 1241-1253 (1970).
N. W. Rydell et al., Clinical Orthopaedics and Related Research, 80, 25-32 (1971).
W. McIlwraith, Journal of the American Veterinary Medical Association, 239-250 (1982).
S. P. Vilesov et al., Klin Khir, 9, p. 71 (1970).
Balazs and Laurent, Chem. & Mol. Biol. of the Intercellular Matrix, 2 (1970) 703-732.
Fraser et al., Chem. Abst., vol. 87, No. 21 (21 Nov. 1977), 170 No. 163114a.
Swann, Biochimica et Biophysica Acta, vol. 160, 1968.
Chemical Abstracts, vol. 102, No. 16, Resume No. 137591n.
Chemical Abstracts, vol. 68, No. 7, Resume No. 27273q.
Chemical Abstracts, vol. 80, No. 15, Resume No. 79756j.
Chemistry and Industry, Feb. 12, 1955, pp. 168-169.
Takashi et al., The Journal of Antibiotics vol. 31 (1978) pp. 150-155.
Cleland Chemical Abstracts, vol. 76 (1972) No. 43073q "Molecular Weight Distribution in Hyaluronic Acid".
Laurent et al., Chemical Abstracts vol. 98 (1983) No. 211813f "The Molecular Weight of Hyaluronate on the Aqueous Tumor."
Shimada et al., J. Biochem. vol. 31 (1977) pp. 79-91 "Molecular Weight of Hyaluronic Acid from Rabbit Skin".
Barron et al., American Journal of Ophthalmology vol. 100 (1985) pp. 377-389 "Comparison of the Effects of Viscoat and Heater."
Swann, Biochem. Biophys. Acta. vol. 156, 1968 pp. 17-30.
Popovici et al., Chemical Abstracts vol. 77, 1972 No. 394 m, p. 60.
Abatangelo et al. Exp. Cell. Res. vol. 137, 1982 pp. 73-78.
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