Salts and bases of the 17-(Cyclopropylmethyl)-4,5 alpha-epoxy-6-

Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Web – sheet or filament bases; compositions of bandages; or...

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424493, 424497, A61P 2536, A61M 3700

Patent

active

061032581

ABSTRACT:
Methods whereby a kappa-preferring opioid blocking agent is used for optimizing dopamine homeostasis during administration of opioid analgesics and for preventing mortal respiratory depression due to drug overdose.

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Article--Bakashi et al. "Dynorphin A-(1-17) Induces Alterations in Free Fatty Acids, Excitatory Amino Acids, and Motor Function Through An Opiate-Receptor-Mediated Mechanism" The Journal of Neuroscience, Dec. 1990. 10(12): 3793-3800.
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