Salt stabilization of antibody-enzyme conjugates heat-dried into

Details Salt stabilization of antibody-enzyme conjugates heat-dried into Salt stabilization of antibody-enzyme conjugates heat-dried into

1993-07-26

1995-11-21

Scheiner, Toni R.

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving oxidoreductase

435188, 435963, 435964, 436547, 436548, 5303911, 5303913, G01N 33531, G01N 33532, G01N 33535

Patent

active

054686229

ABSTRACT:
New and useful methods of producing stabilized enzyme antibody conjugates are disclosed which are particularly useful in forming multi-layer immunoassay test devices. In particular, the invention concerns the formation of a manganese ion and enzyme-antibody conjugate in aqueous solution and drying the solution to produce a dry stabilized enzyme-antibody conjugate. Further, this stabilized enzyme-antibody conjugate can be formed on a continuous web and dried in a heat tunnel. This continuous manufacturing process allows for the more efficient production of multi-layer test strips.

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