Salt stabilization of antibody-enzyme conjugates heat-dried into

Details Salt stabilization of antibody-enzyme conjugates heat-dried into Salt stabilization of antibody-enzyme conjugates heat-dried into

1995-09-21

1997-06-10

Chin, Christopher L.

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving antigen-antibody binding, specific binding protein...

422 56, 422 57, 427 211, 427 213, 4273722, 427394, 427395, 435 4, 435 792, 435 793, 435188, 4352871, 4352872, 4352879, 435805, 436514, 436518, 436527, 436528, 436529, 436530, 436531, 436810, G01N 33531, G01N 33535, G01N 33543, G01N 33558

Patent

active

056374682

ABSTRACT:
New and useful methods of producing stabilized enzyme antibody conjugates are disclosed which are particularly useful in forming multi-layer immunoassay test devices. In particular, the invention concerns the formation of a manganese ion and enzyme-antibody conjugate in aqueous solution and drying the solution to produce a dry stabilized enzyme-antibody conjugate. Further, this stabilized enzyme-antibody conjugate can be formed on a continuous web and dried in a heat tunnel. This continuous manufacturing process allows for the more efficient production of multi-layer test strips.

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