Salt of morpholine compound

Details Salt of morpholine compound Salt of morpholine compound

2007-07-11

2011-10-04

Chung, Susannah (Department: 1626)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

C544S133000

Reexamination Certificate

active

08030303

ABSTRACT:
(2S)-[4-(Carboxymethyl)thiazol-2-ylthio]-N-{[4-(3,4-dichlorobenzyl)morpholin-2-yl]methyl}acetamide hydrobromide and a crystal thereof, which resist easy weight change caused by vapor sorption as compared to a free form, and are superior as drug substances of pharmaceutical products, and a production intermediate therefor are provided.

REFERENCES:
patent: 7935700 (2011-05-01), Tanaka et al.
patent: 2004/0167209 (2004-08-01), Dancer et al.
patent: 2007/0265257 (2007-11-01), Tanaka et al.
patent: 2005/097120 (2005-04-01), None
patent: 2006/514952 (2006-05-01), None
patent: 2006/028284 (2006-03-01), None
patent: WO 2006/028284 (2006-03-01), None
See Bastin, et al., Salt Selection and Optimisation Procedures for Pharmaceutical New Chemical Entities, Organic Process Research & Development, 2000, vol. 4, pp. 427-435, especially p. 428.
Brittain et al., Polymorphism in Pharmaceutical Solids, vol. 95, 1999, pp. 348-361, esp. p. 348 and 350.
Soji Awazu et al., Saishin Yakuzaigaku, 7thEdition, 2001, p. 199.
Supplementary European Search Report issued Sep. 17, 2009 in European Application No. 07 79 0605.
S. Petit et al., “The Amorphous State”, Polymorphism: in the Pharmaceutical Industry, ed. R. Hilfiker, Wiley-VCH, Weinheim, pp. 259-285, Jan. 1, 2006.

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