Salt of diclofenac with a pyrrolidine compound and pharmaceutica

Details Salt of diclofenac with a pyrrolidine compound and pharmaceutica Salt of diclofenac with a pyrrolidine compound and pharmaceutica

1987-11-09

1990-08-14

Ford, John M.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

548574, A61K 3140

Patent

active

049488058

ABSTRACT:
The salt of diclofenac with a cyclic organic base is prepared by dissolving diclofenac in a suitable organic solvent, adding said cyclic organic base, reacting the two components together, removing the solvent and crystallizing the product obtained.
Said salt is water soluble to an extent from 20% w/v to an extent exceeding 50% w/v, and is used to prepared pharmaceutical compositions preferably in granular form for use by dissolving in water for oral administration.

REFERENCES:
patent: 3558690 (1971-01-01), Sallmann
Chemical Abstracts, vol. 102, no. 26, Jul. 1, 1985, p. 336, Abstract no. 225919f.

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