Salt of DC-52 and a pharmaceutical composition containing the sa

Details Salt of DC-52 and a pharmaceutical composition containing the sa Salt of DC-52 and a pharmaceutical composition containing the sa

1985-02-04

1987-03-10

Berch, Mark L.

Organic compounds -- part of the class 532-570 series

Organic compounds

Nitrogen attached directly or indirectly to the purine ring...

A61K 31495, C07D49822

Patent

active

046491996

ABSTRACT:
A pharmacologically acceptable acid addition salt of DC-52 with 0.5-2.0 equivalent weight of inorganic acid, sulfonic acid, acidic amino acid, citric acid, transaconitic acid, .alpha.-ketoglutaric acid, itaconic acid, malonic acid or ascorbic acid on the basis of DC-52, having the same degree of antitumor activity as DC-52, is superior to DC-52 in stability at powdering or at preservation.

REFERENCES:
Kyowa et al., Chem. Abs., 98, 87622 (1982).
Hirata et al., Chem. Abs., 102, 203808 (12-19-84).
Kyowa, Chemical Abstracts, vol. 98, 1983, p. 416, No. 87622z.
Takahashi, Chemical Abstracts, vol. 99, 1983, p. 324, No. 101979a.
Takahashi, J. Antibiot., 36, 468-70 (1983).
Tomita, Chemical Abstracts, vol. 99, 1983, p. 474, No. 68776g.
Tomita, J. Antibiotics, 1983, 36, 463-67.

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