Salmonella virulence genes

Details Salmonella virulence genes Salmonella virulence genes

1995-06-07

2000-01-04

Elliott, George C.

Chemistry: molecular biology and microbiology

Vector, per se

536 237, C12N 1574, C07H 2104

Patent

active

060109017

ABSTRACT:
A vector capable of integrating into the chromosome of Salmonella including a first DNA sequence encoding a heterologous protein, a second DNA sequence encoding a marker, and a third DNA sequence encoding a phoP regulatory region regulated gene product necessary for virulence, the third DNA sequence being mutationally inactivated.

REFERENCES:
patent: 4837151 (1989-06-01), Stocker
patent: 4888170 (1989-12-01), Curtiss, III
Abshire et al., "Analysis of Proteins Synthesized by Salmonella typhimurium during Growth within a Host Macrophage", J. Bacteriol., 175:3734-43 (1993).
Crosa et al., "Molecular Relationships Among the Salmonelleae," J. of Bacteriology, 115(1):307-315.
Groisman et al., "Salmonella typhimurium phoP virulence gene is a transcriptional regulator," Proc. Natl. Acad. Sci. USA, 86:7077-7081 (1989).
Miller et al., "Salamonella Vaccines With Mutations in The PhoP Virulence Regulon," Institut Pasteur/Elsevier 141:817-821 (1990).
Pulkkinen et al., "A Salmonella typhimurium Virulence Protein Is Similar to a Yersinia enterocolitica Invasion Protein and a Bacteriophage Lamda Outer Membrane Protein," J. of Bacteriology 173(1) =86-93, 1991.
Arico et al., Proc. Natl. Acad. Sci., 86:6671-75, 1989.
Miller et al., Annals of the New York Academy of Sciences, 569:145-154, 1989.
Stock et al., Microbiological Reviews, 53:450-90, 1989.
Hoiseth et al., Nature, 291:238-239, 1981.
Bernardini et al., Jour. of Bact., 172:6274-6281, 1990.
Leroux et al., The EMBO Journal, 6:849-856, 1987.
Curtis et al., Immunobiology of Proteins and Peptides V Vaccines, M.Z. Atassi, ed., pp. 33-47, 1989.
Miller et al., Proc. Natl. Acad. Sci. USA 86:5054-5058, 1989.
Curtis et al., Current Topics in Microbiology and Immunology, 146:35-49, 1989.
Curtiss, Biotech, 8:237-240, 1990.
Galan et al., Microbial Pathogenesis, 6:433-43, 1989.
Curtiss et al., Immunological Investigations, 18:583-596, 1989.
Kier et al., Jour of Bacteriology, 138:155-61, 1979.
Curtiss et al., Infection and Immunity, 55:3035-43, 1987.
Fields et al., Science, 243:1059-1062, 1989.
Galan, Abstracts of 89th Annual Meeting of the American Society for Microbiology, E-9, 1989.
Miller et al., Journal of Bacteriology, 170:2575-2583, 1988.
Taylor et al., Journal of Bacteriology, 171:1870-1878, 1989.
Kier et al., Journal of Bacteriology, 130:399-410, 1977.
Michaelis et al., Journal of Bacteriology, 154:366-374, 1983.
Kukral et al., Journal of Bacteriology, 169:1787-1793, 1987.
Mekalanos, Cell, 35:253-262, 1983.
Beattie et al., Journal of Bacteriology, 172:6997-7004, 1990.
Foster et al., Journal of Bacteriology, 172:771-778, 1990.
Lee et al., Proc. Natl. Acad. Sci. USA, 87:4304-4308, 1990.
Lee et al., Proc. Natl. Acad. Sci. USA, 89:1847-1851, 1992.
Miller et al., Journal of Bacteriology, 172:2485-2490, 1990.
Aranda et al., Proc. Natl Acad. Sci. USA 89:10079-10083, 1992.
Stone et al., Journal of Bacteriology, 174:3945-3952, 1992.
Miller et al., Infection and Immunity, 60:3763-3770, 1992.
Galan et al., Infection and Immunity, 59:2901-2908, 1991.
Sanderson et al., Microbiological Reviews, 52:485-532, 1988.
Miller et al., "Salmonella Vaccines With Mutations in the phoP Virulence Regulon", Res. Microbiol., 141:817-821 (1990).
Miller et al., "the PhoP virulence regulon and live oral Salmonella vaccines", Vaccine, 11(2):122-125 (1993).
Miller et al., "PhoP/PhoQ: macrophage-specific modulators of Salmonella virulence?", Molecular Microbiology 5(9):2073-2078 (1991).
Dougan et al. (1988) Construction and characterization of vaccine strains of Salmonella harboring mutations in two different aro genes. J. Infect. Dis. 158:1329-1335, Dec. 1988.
Miller et al. (1990) Characterization of defensin resistance phenotypes associated with mutations in the phoP virulence regulon of Salmonella typhimurium. Infection Immunity 58:3706-3710, Nov. 1990.
O'Callaghan et al. (1988) Characterization of aromamtic-and purine-dependent Salmonella typhimurium: attenuation, persistence, and ability to induce protective immunity in BALB/c mice. Infection Immunity 56:419-423, Feb. 1988.

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