Salmonella vectors encoding truncated pag fusion protein, method

Details Salmonella vectors encoding truncated pag fusion protein, method Salmonella vectors encoding truncated pag fusion protein, method

1994-08-05

1998-03-31

Housel, James C.

Chemistry: molecular biology and microbiology

Treatment of micro-organisms or enzymes with electrical or...

Modification of viruses

435245, 4352523, 4353201, 4241851, 4241901, 4241921, 4242001, 4242081, 4242341, 4242581, C12N 1500, C12N 1563, A61K 3921, A61K 39112

Patent

active

057337608

ABSTRACT:
A modified Salmonella, wherein the wild type pag gene such as pagC has been replaced by a gene encoding a truncated pag gene such as pagC gene fused to a heterologous DNA segment, is disclosed. This modification significantly attenuates the virulence of the Salmonella. In addition, immune reaction to the portion of the fusion protein encoded by the heterologous gene can be generated. Uses of the vector, including its use in a drug screen are also disclosed.

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