Drug – bio-affecting and body treating compositions – Whole live micro-organism – cell – or virus containing – Genetically modified micro-organism – cell – or virus
Patent
1995-12-01
1998-12-01
LeGuvader, John L.
Drug, bio-affecting and body treating compositions
Whole live micro-organism, cell, or virus containing
Genetically modified micro-organism, cell, or virus
4351723, 4352523, A61K 39112, C12N 1503, C12N 121
Patent
active
058434267
ABSTRACT:
The invention features a Salmonella cell the virulence of which is attenuated by a deletion of a portion of the PhoQ gene and Salmonella cells having a deletion of the PhoQ gene and a deletion of the PhoP gene. The invention also features vaccines comprising such bacteria.
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Mekalanos John J.
Miller Samuel I.
Brusca John S.
LeGuvader John L.
President and Fellows of Harvard College
The General Hospital Corporation
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