Chemistry: molecular biology and microbiology – Micro-organism – per se ; compositions thereof; proces of... – Bacteria or actinomycetales; media therefor
Patent
1994-07-06
1997-12-09
Ketter, James
Chemistry: molecular biology and microbiology
Micro-organism, per se ; compositions thereof; proces of...
Bacteria or actinomycetales; media therefor
435245, C12N 120, C12N 136
Patent
active
056959834
ABSTRACT:
A bacterial cell the virulence of which is attentuated by a first mutation in a PhoP regulon and a second mutation in an aromatic amino acid synthetic gene and bacterial cells the virulence of which is attenuated by a mutation in one or more PhoP-activated genes or one or more PhoP-repressed genes.
REFERENCES:
patent: 4550081 (1985-10-01), Stocker
patent: 4735801 (1988-04-01), Stocker
patent: 4764370 (1988-08-01), Fields et al.
patent: 4837151 (1989-06-01), Stocker
patent: 5077044 (1991-12-01), Stocker
patent: 5210035 (1993-05-01), Stocker
patent: 5424065 (1995-06-01), Curtiss, III et al.
Miller et al. Proc. Natl. Acad. Sci. USA 86 5054-5058 (1989) A Two-Component Regulatory System (phoP phoQ) Controls . . . .
Crosa et al., "Molecular Relationships Among the Salmonelleae," J. of Bacteriology, 115(1):307-315.
Groisman et al., "Salmonella typhimurium phoP virulence gene is a transcriptional regulator," Proc. Natl. Acad. Sci. USA, 86:7077-7081 (1989).
Miller et al., "Salamonella Vaccines With Mutations in The PhoP Virulence Regulon," Res. Microbiol. 141:817-821 (1990).
Pulkkinen et al., "A Salmonella typhimurium Virulence Protein Is Similar to a Yersinia enterocolitica Invasion Protein and a Bacteriophage Lambda Outer Membrane Protein," J. of Bacteriology 173(1):86-93, 1991.
Supplementary European Search Report, Application No. EP 92 90 4089, date 15 Jun. 1995.
PCT Written Opinion, Application No. PCT/US94/07658, mailed 17 Jul. 1995.
Alpuche-Aranda, C., et al., "Salmonella Stimulate Macrophage Macropinocytosis and Persist Within Spacious Phagosomes", 1994, J. Exp. Med., 179:601-08.
Behlau, I., et al., "A PhoP-Repressed Gene Promotes Salmonella typhimurium Invasion of Epithelial Cells", 1993, J. Bacteriology, 175:4475-84.
David, S., et al., "Leuconostoc Lactis .beta.-Galactosidase Is Encoded by Two Overlapping Genes", 1992, J. Bacteriology, 174:4475-81.
Edwards, M., et al., "Construction of .DELTA.aroA his .DELTA.pur Strains of Salmonella typhi", J. Bacteriology, 170:3991-95.
Groisman E., et al., "Horizontal Transfer of a Phosphatase Gene as Evidence for Mosaic Structure of the Salmonella Genome", 1992, EMBO J., 11:1309-16.
Groisman E., et al., "Cognate Gene Clusters Govern Invasion of Host Epithelial Cells by Salmonella typhimurium and Shigella flexneri", 1993, EMBO J., 12:3779-87.
Gulig, P., et al., "Identification, Genetic Analysis and DNA Sequence of a 7.8-kb Virulence Region of the Salmonella typhimurium Virulence Plasmid", 1992, Molecular. Microbiol., 6:1395-411.
Heffernan, E., et al., "The Salmonella typhimurium Virulence Plasmid Complement Resistance Gene rck is Homologous to a Family of Virulence-Related Outer Membrane Protein Genes, Including pagC and ail", 1992, J. Bacteriol., 174:84-91.
Hone, D., et al., "Evaluation in Volunteers of a Candidate Live Oral Attenuated Salmonella typhi Vector Vaccine", 1992, J. Clin. Invest., 90:412-20.
Levine, M., et al., "Safety, Infectivity, Immunogenicity, and In Vivo Stability of Two Attenuated Auxotrophic Mutant Strains of Salmonella typhi, 541Ty and 543Ty, as Live Oral Vaccines in Humans", 1987, J. Clin. Invest., 79:888-902.
Mekalanos, J., "Environmental Signals Controlling Expression of Virulence Determinants in Bacteria", 1992, J. Bacteriology, 174:1-7.
Miller, S., et al., "The PhoP Virulence Regulon and Live Oral Salmonella Vaccines", 1993, Vaccine, 11:122-25.
Miller, S., et al., "Constitutive Expression of the PhoP Regulon Attenuates Salmonella Virulence and Survival Within Macrophages", 1990, J. Bacteriology, 172:2485-90.
Miller, V. et al., "An Unusual pagC::TnphoA Mutation Leads to an Invasion- and Virulence-Defective Phenotype in Salmonellae", 1992, Infection and Immunity, 60:3763-70.
Miller, S., "PhoP/PhoQ:macrophage-specific Modulators of Salmonella Virulence?", 1991, Molecular Microbiology 5:2073-78.
Sugino, H., et al., "A Monoamine-Regulated Klebsiella Aerogenes Operon Containing the Monoamine Oxidase Structural Gene (maoA) and the maoC Gene", 1992, J. Bacteriology, 174:2485-92.
Tacket, C., et al., "Comparison of the Safety and Immunogenicity of .DELTA.aroC .DELTA.aroD and .DELTA.cya .DELTA.crp Salmonella typhi Strains in Adult Volunteers", 1992, Infection and Immunity, 60:536-41.
Tacket, C., et al., "Clinical Acceptability and Immunogenicity of CVD 908 Salmonella typhi Vaccine Strain", 1992, Vaccine, 10:443-46.
Mekalanos John J.
Miller Samuel I.
Brusca John S.
Ketter James
President and Fellows of Harvard College
The General Hospital Corporation
LandOfFree
Salmonella vaccines does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Salmonella vaccines, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Salmonella vaccines will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1606993