Salmonella vaccine

Drug – bio-affecting and body treating compositions – Whole live micro-organism – cell – or virus containing

Reexamination Certificate

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Details

C424S093200, C424S184100, C424S234100, C424S235100, C424S258100

Reexamination Certificate

active

07045122

ABSTRACT:
The present invention relates to live attenuatedSalmonellastrains comprising a first attenuating mutation, that are not capable of making functional RecA. The invention also relates to these bacteria for use in vaccines. Furthermore, the invention relates to vaccines based upon these bacteria, to the use of such bacteria in the manufacture of vaccines and to methods for the preparation of such vaccines.

REFERENCES:
patent: 0 650 733 (1995-05-01), None
patent: 97 18837 (1997-05-01), None
patent: 98 56901 (1998-12-01), None
patent: WO 98/56901 (1998-12-01), None
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Nosoh, Y. et al in “Protein Stability and Stabilization through Protein Engineering, 1991” (chapter 7, p. 197, second paragraph).
Ferguson et al, (Mutation Research, 1987, 184 13-21).
Buchmeier et al, (Molecular Microbiology, 1993, 7(6), 933-936).
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Griffin et al, Vaccine, 1993, vol. 11, No. 4, p. 457-62.
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Ferguson L R et al: “Frameshift Mutagenesis by Nitracrine Analogues in Wild-Type uvr-B pol-A and rec-A Strains ofSalmonella-typhimuriumWith and Without Plasmid p-KM-101”; Mutations Research; vol. 184, No. 1, 1987, pp. 13-21.
Johnson B N et al: “Construction ofSalmonellaStrains with Both Antigen 04 of Gropu B and Antigen 09 of Group D”; Journal of Bacteriology, vol. 174, No. 6, 1992, pp. 1911-1915.
Buchmeier Nancy A et al: “Recombination-Deficient Mutants ofSalmonella typhimuriumare Avirulent and Sensitive to the Oxidative Burst of Macrophages.”; Molecular Microbiology, vol. 7, No. 6, 1993, pp. 933-936.
Guerry, P. et al.: “Development and Characterization of recA Mutants ofCampylobacter jejunifor Inclusion in Attenuated Vaccines”; Infection and Immunity; vol. 62, No. 2, Feb. 1994.

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