Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Carbohydrate doai
Patent
1994-09-27
1996-07-30
Peselev, Elli
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Carbohydrate doai
424 49, 514901, A61K 3170
Patent
active
055411657
ABSTRACT:
A saliva substitute composition includes glycerin, gum, water, and a pH buffering system. Sweeteners, colorants, and preservatives may be optionally combined. The glycerin component serves both as a lubricant and as a delivery vehicle for water from the composition to moisten the mouth. The gum component provides further lubrication and serves a water retention function. Gum arabic, xanthum, or sorghum are examples. The pH buffering system includes acidic and basic components. Citric acid or citrate salts and carbonate was found to be an effective buffering system. The composition is used to maintain moisture in the mouth when little or no natural saliva is produced, providing relief from dry mouth, as a symptom of xerostomia, mucositis, and stomatitis, as well as general inflammation and/or ulceration of mucous membranes, while avoiding pH imbalances which may lead to tooth decay and/or injury to the upper digestive tract including the oral cavity, oropharynx, or esophagus. These compositions may be further incorporated in mouthwashes and soft drinks, as well as oral medicaments.
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patent: 3767789 (1973-10-01), Rankin
patent: 4537689 (1985-08-01), Morrow et al.
patent: 4879281 (1989-11-01), Shibaski et al.
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patent: 5260282 (1993-11-01), Attstrom et al.
patent: 5409691 (1995-04-01), Swain
Martindale, The Extra Pharmacopoeia, 29th Edition, Reynolds, ed., 1989, pp. 1128-1130.
The Merck Index of Chemicals and Drugs, 7th Edition, Stecher, ed., 1960, pp. 489-490.
Litman Richard C.
Peselev Elli
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