Saliva binding protein

Details Saliva binding protein Saliva binding protein

1997-09-12

1999-03-16

Minnifield, Nita

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving antigen-antibody binding, specific binding protein...

4353201, 435 914, 435 691, 435 701, 536 231, 536 2432, 536 243, G01N 3353, C07H 2102, C07H 2104, C12N 1500

Patent

active

058828710

ABSTRACT:
The invention provides Saliva Binding Protein polypeptides and DNA (RNA) encoding Saliva Binding Protein polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing Saliva Binding Protein polypeptides to screen for antibacterial compounds.

REFERENCES:
patent: 5700928 (1997-12-01), Hodgson et al.
Ganeshkumar, et al., "Nucleotide Sequence of a Gene Coding for a Saliva-Binding Protein (SsaB) from Streptococcus sanguis 12 and Possible Role of the Protein in Coaggregation with Actinomyces", Infection and Immunity, vol. 59, No. 3, pp. 1093-1099, Mar., 1991.
M.C. Herzberg, "Platlet-Streptococcal Interactions in Endocarditis", Crit. Rev. Oral Biol. Med., vol. 7, No. 3, pp. 222-236.
Lowe, et al., "Cloning of an Enterococcus Faecalis Endocarditis Antigen: Homology With Adhesins From Some Oral Streptococci", Infect. Immun., vol. 63, No. 2, pp. 703-706, Feb. 1995.
Kolenbrander, et al., "Nucleotide Sequence of the Streptococcus Gordonii PK488 Coaggregation Adhesin Gene, scaA, and ATP-Binding Cassette", Infect. Immun., vol. 62, No. 10, pp. 4469-4480, Oct. 1994.
H.F. Jenkinson, "Cell Surface Protein Receoptors in Oral Streptococci", FEMS Microbiol. Lett., vol. 121, No. 2, pp. 133-140, Aug. 15, 1994.
Sampson, et al., "Cloning and Nucleotide Sequence Analysis of psaA, the Streptococcus pnuemoniae Gene Encoding a 37-Kilodalton Protein Homologous to Previously Reported Streptococcus sp. Adhesins", Infect. Immun., vol. 62, No. 1, pp. 319-324, Jan. 1994.
Ganeshkumar, et al., "Saliva-Binding Protein (SsaB) from Streptococcus Sanguis 12 Is a Lipoprotein", J. Bacteriol, vol. 175, No. 2, pp. 572-8.
Ganeshkumar, et al., "Cloning of a Streptococcus sanguis Adhesin Which Mediates Binding to Saliva-Coated Hydroxyapatite", Infec. and Immun., vol. 56, No. 5, pp. 1150-1157, May, 1988.
Dintilhac et al, Res. Microbiol. 148:119-31, 1997.

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