Salinosporamides and methods for use thereof

Details Salinosporamides and methods for use thereof Salinosporamides and methods for use thereof

2007-02-20

2007-02-20

Powers, Fiona T. (Department: 1626)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

C548S453000

Reexamination Certificate

active

10600854

ABSTRACT:
The present invention is based on the discovery that certain fermentation products of the marine actinomycete strains CNB392 and CNB476 are effective inhibitors of hyperproliferative mammalian cells. The CNB392 and CNB476 strains lie within the family Micromonosporaceae, and the generic epithetSalinosporahas been proposed for this obligate marine group. The reaction products produced by this strain are classified as salinosporamides, and are particularly advantageous in treating neoplastic disorders due to their low molecular weight, low IC50values, high pharmaceutical potency, and selectivity for cancer cells over fungi.

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