Salinamides

Details Salinamides Salinamides

1994-01-25

1999-07-06

Bond, Robert T.

Organic compounds -- part of the class 532-570 series

Organic compounds

Unsubstituted hydrocarbyl chain between the ring and the -c-...

530317, 530321, 514183, 514 10, C07D49808, A61K 31395

Patent

active

059199261

ABSTRACT:
Salinamides A and B are disclosed. These two bicyclic depsipeptides are produced by fermentation of a specific marine actinomycete, a Streptomyces sp, (CNB-091) in saltwater-based media. Salinamides A and B are useful as anti-biotic and anti-inflammatory agents.

REFERENCES:
Chemical Abstracts vol. 120 (1994) p. 1048 Item 299273j.
Fenical, W., "Chemical Studies of Marine Bacteria: Developing a New Resource," Chem. Rev., vol. 93, No. 5, pp. 1673-1683.
Gil-Turnes et al., "Symbiotic Marine Bacteria Chemically Defend Crustacean Embryos from a Pathogenic Fungus," Science, Oct. 6, 1989, vol. 246, pp. 116-118.
Pathirana et al., Marinone and Debromomarinone: Antibiotic Sesquiterpenoid Naphthoquinones of a New Structure Class from a Marine Bacterium, Tetrahedron Letters, vol. 33, No. 50, pp. 7663-7666, 1992.
Trischman et al., "Salinamides A and B: Anti-Inflammatory Depsipeptides from a Marine Streptomycete," J. Am. Chem. Soc., vol. 116, No. 2, 1994, pp. 757-758.
Tapiolas et al., "Octalactins A and B: Cytotoxic Eight-Membered-Ring Lactones from a Marine Bacterium, Streptomyces sp.," J. Am. Chem. Soc., vol. 113, 1991, pp. 4682-4683.
Pathirana et al., "Rare Phenazine L-Quinovose Esters from a Marine Actinomycete," J. Org. Chem., vol. 57, No. 2, 1992, pp. 740-742.
Jensen et al., "Distribution of Actinomycetes in Near-Shore Tropical Marine Sediments, " Appl. Environ. Microbiol., vol. 57, 1991, pp. 1102-1108.
Gil-Turnes et al., "Embryos of Homarus americanus are Protected by Epibiotic Bacteria," Biol. Bull., vol. 182, No. 1, Feb. 1992, pp. 105-108.
Takahashi et al., "Altemicidin, a New Acaricidal and Antitumor Substance: I. Taxonomy, Fermentation, Isolation and Physico-Chemical and Biological Properties," J. Antibiotics, vol. XLII, No. 11, Nov. 1989, pp. 1556-1561.
Okami et al., "New Aminoglycoside Antibiotics, Istamycins A and B," J. Antibiotics, vol. XXXII, No. 9, Sep. 1979, pp. 964-966.

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