Salified anionic resin for cholesterol and lipid lowering

Drug – bio-affecting and body treating compositions – Solid synthetic organic polymer as designated organic active... – Polymer from ethylenic monomers only

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424180, 424308, 424317, 424319, 521 30, 521 31, 521 32, 521 38, 536112, A61K 3174, C08F 810, C08F 830, C08F 832

Patent

active

043405851

ABSTRACT:
A non-toxic anionic resin selected from resins having a polymeric reticulated skeleton of styrenic or acrylic type, inert to the digestive enzymes, having a molecular weight higher than 1000 and containing ionizable amino groups, resins having a cellulosic reticulated skeleton modified by the introduction of free or substituted amino groups and resins having a polysaccharide reticulated skeleton modified by the introduction of free or substituted amino groups. The resin is capable of binding itself permanently to the biliary acids and is salified with an acid corresponding to the general formula: ##STR1## wherein: R' represents a hydrogen atom, an alkyl group having 1 to 3 carbon atoms, a hydroxyalkyl group having 1 to 3 carbon atoms,

REFERENCES:
Martindale, The Extra Pharm., Pharm. Press, London, 27th Ed., 1977, pp. 362, 366.
Cayen, Canadian J Biochem., vol. 48, 1970, pp. 1022-1023.

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