Salicylamide esters and related pharmaceutical composition

Details Salicylamide esters and related pharmaceutical composition Salicylamide esters and related pharmaceutical composition

1980-03-12

1981-05-19

Killos, Paul J.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carboxylic acid esters

560 47, 560 48, 560105, 560 55, 424263, 424309, 424308, 424310, 546310, C07C 6976

Patent

active

042686857

ABSTRACT:
Esters of salicylamide with anti-inflammatory and analgesic action are disclosed.
These esters have the following general formula: ##STR1## wherein R is a radical of an acid selected among d-2-(6'-methoxy-2'-naphtyl)-propionic acid, 2[[3-(trifluoromethyl)phenyl]-amino]-3-pyridine carboxylic acid, 2- {[3-(trifluoromethyl)-phenyl]-amino}-3-pyridincarboxylic acid, 2-(4-isobutyl-phenyl)-propionic acid, 4-allyloxy-3-chloro-phenylacetic acid, 2-(3-benzoylphenyl)-propionic acid, 2-[(2,3-dimethylphenyl)amino]-benzoic acid and 2[[3-trifluoromethyl)phenyl]-amino]benzoic acid.
The process for preparing the subject esters comprises reacting a halide, preferably a chloride of the desired acid, with a solution of salicylamide.

REFERENCES:
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patent: 3511873 (1970-05-01), Picciola
patent: 3652762 (1972-03-01), Sallmann et al.
patent: 3657430 (1972-04-01), Shen
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patent: 3778470 (1973-12-01), Sallmann
patent: 4029815 (1977-06-01), Sherlock et al.
patent: 4049699 (1977-09-01), Sinkula
patent: 4049700 (1977-09-01), Sinkula
patent: 4150137 (1979-04-01), Noda et al.
patent: 4198431 (1980-04-01), Kato

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