Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Carbohydrate doai
Patent
1982-11-16
1986-01-28
Jiles, Henry R.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Carbohydrate doai
260455R, 2603511, 514513, 514 36, 514152, 536 74, 536 132, A61K 31265, A61K 3171, A61K 3165, C07C153023
Patent
active
045671630
ABSTRACT:
The thioester of N-acetylcysteine with salicylic acid and the pharmacologically acceptable and non-toxic organic and inorganic salts thereof, exhibit anti-pyretic, anti-inflammatory and analgesic activity as well as mucolytic activity. The compounds are prepared by the reaction of N-acetylcysteine with either the acid chloride of acetylsalicylic acid or with the mixed anhydride formed from acetylsalicylic acid and ethyl chloroformate, the reaction taking place in an aqueous medium and at low temperature.
REFERENCES:
patent: 4268456 (1981-05-01), Keim et al.
CA: 88:23,388p., Blum.
El-Naggar et al., CA: 83:43714s.
Jiles Henry R.
Pietro Ismardi & C. S.p.A.
Smolowitz Martin
Whittenbaugh Robert C.
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