Saitohin gene and uses of same

Details Saitohin gene and uses of same Saitohin gene and uses of same

2008-01-01

2008-01-01

O'Hara, Eileen B. (Department: 1649)

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Recombinant dna technique included in method of making a...

C435S320100, C435S252800, C435S006120, C435S091200, C530S350000, C536S023500, C536S023100, C536S024310

Reexamination Certificate

active

07314733

ABSTRACT:
The present invention provides an isolated nucleic acid sequence encoding saitohin (STH), an isolated nucleic acid sequence that hybridizes to said sequence, and a purified protein encoded by said nucleic acid sequences. The present invention also provides a purified STH protein, and a method of making STH protein. The present invention is further directed to an antibody specific for STH, and a method for producing said antibody. Additionally, the present invention discloses a vector comprising a nucleic acid sequence encoding STH, a host cell transformed with said vector, and transgenic nonhuman animals. The present invention further provides methods for determining whether a subject has, or is at increased risk for developing, a neurodegenerative disease, and for assessing said subject's prognosis. Finally, the present invention discloses kits for determining whether a subject has, or is at increased risk for developing, a neurodegenerative disease.

REFERENCES:
patent: 5474796 (1995-12-01), Brennan
patent: 6593512 (2003-07-01), Vitek et al.
patent: WO 99/62548 (1999-12-01), None
Wells, 1990, Biochemistry 29:8509-8517.
Ngo et al., 1994, The Protein Folding Problem and Tertiary Structure Prediction, pp. 492-495.
Bork, 2000, Genome Research 10:398-400.
Skolnick et al., 2000, Trends in Biotech. 18(1):34-39, especially p. 36 at Box 2.
Doerks et al., 1998, Trends in Genetics 14: 248-250.
Smith et al., 1997, Nature Biotechnology 15:1222-1223.
Brenner, 1999, Trends in Genetics 15:132-133.
Bork et al., 1996, Trends in Genetics 12:425-427).
Wang et al. Nuc. Acids Res. 27: 4609-4618, 1999.
Kaufman et al. Blood. 1999; 94: 3178-3184.
Wigley et al. Reprod Fert Dev. 1994; 6: 585-588.
Campbell et al. Theriogenology. 1997; 47(1): 63-72.
Phillips, A., J Pharm Pharmacology 53: 1169-1174, 2001.
Cook et al. Annals of Neurol. 52: 690-691.
Johansson et al. Neurodegener Dis. 2005; 2:28-35.
Combarros et al. Dement Geriatr Cogn Disord. 2003; 16: 132-5.
Peplonska et al. Neurosci Lett. 2003; 348: 163-6.
Kerlavage, AR. The cerebellum II Homo sapiens cDNA 5′ end, mRNA sequence EST28266. NCBI [online], Bethesda, MD, USA [retrieved on May 1, 2003]. Retrieved from NCBI, GenBankk Accession No. AA325304.
Conrad et al. A polymorphic gene nested within an intron of the tau gene: Implications for Alzheimer's disease. PNAS, May 2002, vol. 99, No. 11, pp. 7751-7756.
Poorkaj et al. A genomic sequence analysis of the mouse and human microtubule-associated protein tau. Mammalain Genome, 2001, vol. 12, pp. 700-712.
Streffer et al. Saitohin gene is not associated with Alzheimer's disease. J. Neurol. Neurosurg. Psychiatry, 2003, vol. 74, pp. 362-363.
Verpillat et al. Is the Saitohin gene involved in neurodegenerative disease? Ann. Neurol. 2002, vol. 52, pp. 829-832.
Birren, B et al. “Homo sapiens chromosome 17, clone—2524N8, complete sequence,” Sep. 26, 1999. Database Accession No. AC010792. Abstract.
Kerlavage, AR, “The cerebellum II homo sapiens cDNA 5′ end, mRNA sequence,” Apr. 20, 1997. GenBank Acc: AA325304.
Bullido, M J et al., A polymorphism in the tau gene associated with risk for Alzheimer's disease. NeuroScience Letters 278 (1-2): 49-52, 2000.
Conrad C. et al. Molecular evolution and genetics of the Saitohin gene and tau haplotype in Alzheimer's disease and argyrophilic grain disease. Journal of Neurochemistry, 2004, 89, 179-188.
Gao L. et al. Saitohin, Which Is Nested in the tau Locus and Confers Allele-specific Susceptibility to Several Neurodegenerative Diseases, Interacts with Peroxiredoxin 6. The Journal of Biological Chemistry, vol. 280, No. 47, 39268-39272, 2005.
Conrad C et al. Saitohin, a novel putative gene in the tau locus. Society for Neuroscience Abstract, 2001.
Seripa D et al., entitled “Alzheimer disease risk associated with APOE4 is modified by STH gene polymorphism,” Neurology 2004;62: pp. 1631-1633.

Affiliated with

Also associated with

Rating

Saitohin gene and uses of same does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Saitohin gene and uses of same, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Saitohin gene and uses of same will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-2787549