Saikosaponin derivatives, their production and use

Details Saikosaponin derivatives, their production and use Saikosaponin derivatives, their production and use

1988-07-21

1990-04-17

Griffin, Ronald W.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

536 41, 536 5, C07G 300, C07J 1524, A01N 4304, A01N 4500, A61K 31705

Patent

active

049181718

ABSTRACT:
A phosphate ester of saikosaponin a, b.sub.1, b.sub.2, c, d or h or saikogenin A, C or D, or a pharmaceutically acceptable salt thereof, which exhibits potent antiinflammatory activity against adjuvant arthritis and then can be used safely as a drug for the treatment and prevention of rheumatism, and a process for preparing the same characterized by phosphorylating the saikosaponin or saikogenin.

REFERENCES:
patent: 3629231 (1971-12-01), Hough et al.
patent: 4101652 (1978-07-01), Bonati

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