Saccular collagen and compositions and methods for making and us

Chemistry: molecular biology and microbiology – Animal cell – per se ; composition thereof; process of... – Insect cell – per se

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435350, 435351, 435352, 435363, 4352523, 4352542, 4353201, 536 235, C12N 1512

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active

057029482

ABSTRACT:
A substantially purified saccular collagen protein and compositions, including pharmaceutical compositions, that comprise the saccular collagen protein are disclosed. Methods of using the saccular collagen which comprise injecting the saccular collagen into the tissue of an individual are disclosed. Antibodies which bind to the saccular collagen protein, nucleic acid molecules which encode the saccular collagen protein, and oligonucleotides which are identical or complementary to at least a portion of the sequence that encodes the saccular collagen proteins are disclosed. Recombinant expression vector that comprise nucleic acid molecules that encode the saccular collagen protein and host cells, including the cells of transgenic animals, which comprise the recombinant expression vectors are disclosed.

REFERENCES:
patent: 4736866 (1988-04-01), Leder et al.
patent: 4873191 (1989-10-01), Wagner et al.
patent: 5434058 (1995-07-01), Davidson
Davis, J. G. (1994) dissertation Abstracts Inter. 55 (5B), 1758.
Abe, N, et al. (1994) Biochim. et Biophy Acta 1204, 61-67.
Davis, J. G., et al. (1995) Science 267, 1031-1034.
Altschul et al., "Basic Local Alignment Search Tool", J. Mol. Biol. 1990, 215, 403-410.
Brass, A. et al., "The Fibrillar Collagens, Collagen VIII, Collagen X and the C1q Complement Proteins Share a Similar Domain in Their C-Terminal Non-Collagenous Regions", FEBS 1992, 303(2,3), 126-128.
Chomczynski, P. et al., "Single-Step Method of RNA Isolation by Acid Guanidium Thiocyanate-Phenol-Chloroform Extraction", Analytical Biochemistry 1987, 162, 156-159.
Corwin, J., "Postembryonic Production and Aging of Inner Ear Hair Cells in Sharks", J. Compl. Neur. 1981, 201, 541-553.
Fisher, C. et al., "In-situ Hybridization Using Digoxigenin Labelled Probes in Human Skin", British J. of Dermatology 1991, 125, 516-520.
LuValle, P. et al., "The Type X Collagen Gene. Intron Sequences Split the 5'-Untranslated Region and Separate the Coding Regions for the non-Collagenous Amino-Terminal and Triple-helical Domains", The J. of Biol. Chem. 1988, 263(34), 18378-18385.
Muragaki, Y. et al., "The .alpha.2 (VIII) Collagen Gene", The J. of Biol. Chem. 1991, 266(12), 7721-7727.
Ninomiya, Y. et al., "The Developmentally Regulated Type X Collagen Gene Contains a Long Open Reading Frame without Introns", The J. of Biol. Chem. 1986, 261 (11), 5041-5050.
Reid, K. et al., "lg-Binding Domains of C1Q", Immunology Today 1990, 11(11), 387-38.
Simmons, D. et al., "A Complete Protocol for In Situ Hybridization of Messenger RNAs in Brain and Other Tissues With Radio-Labeled Single-Stranded RNA probes", The J. of Histotechnology 1989, 12(3), 169-181.
Springer, J.E. et al., "Non-Radioactive Detection of Nerve Growth Factor Receptor (NGFR) mRNA in Rat Brain using In Situ Hybridization Histochemistry", The J. of Histochemistry and Cytochemistry 1991, 39(2), 231-234.
Van Gelder, R. et al,. "Amplified RNA Synthesized from Limited Quantities of Heterogeneous cDNA", PNAS USA 1990, 87, 1663-1667.
Yamaguchi, N. et al., "The .alpha.1(VIII) Collagen Gene is Homologous to the .alpha.1(X) Collagen Gene and Contains a Large Exon Encoding the Entire Triple helical and Carboxyl-terminal Non-triple helical Domains of the .alpha.1 (VIII) Polypeptide", The J. of Biol. Chem. 1991, 266(7), 4508-4513.
Yamaguchi, N. et al., "The Cloning and Sequencing of .alpha.1(VIII) Collagen cDNAs Demonstrate That Type VIII Collagen is a Short Chain Collagen and Contains Triple-Helical and Carboxyl-Terminal Non-triple-helical Domains Similar to Those of Type X Collagen", The J. of Biol. Chem. 1989, 264, 16022-16029.
Davis, J.G. et al., "Use of the Teleost Saccule to Identify Genes Involved in Inner Ear Function", DNA and Cell Biology 1995, 14(10), 833-839.

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