Saccharomyces cerevisiae mutant

Details Saccharomyces cerevisiae mutant Saccharomyces cerevisiae mutant

2008-06-03

2008-06-03

Saidha, Tekchand (Department: 1652)

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Preparing oxygen-containing organic compound

C435S254210, C435S471000, C435S483000

Reexamination Certificate

active

07381551

ABSTRACT:
The present invention relates to a method for improved ethanol production from xylose utilizing strain ofSaccharomyces cerevisiaecomprising genes for overexpression of xylose reductase, xylitol dehydrogenase and xylulokinase, wherein in addition to said genes, one or more specific genes of a defined group is overexpressed, and/or one or more genes of a defined group is deleted.

REFERENCES:
patent: 5789210 (1998-08-01), Ho et al.
patent: WO 01/88094 (2001-11-01), None
patent: WO/0188094 (2001-11-01), None
Wahlbom et al., Molecular analysis of aSaccharomyces cerevisiaemutant with improved ability to utilize xylose shows enhanced expression of proteins involved in transport, initial xylose metabolism, and the pentose phosphate pathway. Appl. Environ. Microbiol., Feb. 2003, vol. 69 (2): 740-746. (In IDS).
Leibowitz et al., pet18: A chromosomal gene required for cell growth and for maintenance of mitochondrial DNA and the killer plasmid of yeast. Molec. gen. Genet., 1978, vol. 165: 115-121.
Jeffries et al., Genetic engineering for improved xylose fermentation by yeasts. Advances in Biochemical Engineering/Biotechnology, 1999, vol. 65: 117-161. Book Chapter, publishers, Springer-Verlag, Berlin Heidelberg.
Whisstock et al., Prediction of protein function from protein sequence and structure. Q Rev. Biophys., 2003, vol. 36 (3): 307-340.
Applied and Environmental Microbiology, vol. 69, No. 2, Feb. 2003, Wahlbom et al., “Molecular Analysis of aSaccharomyces cerevisiaeMutant with Improved Ability To Utilize Xylose Shows Enhanced Expression of Proteins Involved in Transport, Initial Xylose Metabolism, and the Pentose Phosphate Pathway”, pp. 740-746.
FEMS Yeast Research, vol. 2, 2002, Johansson et al., “The non-oxidative pentose phosphate pathway controls the fermentation rate of xylulose but not of xylose inSaccharomyces cerevisiaeTMB3001”, pp. 277-282.
Applied and Environmental Microbiology, vol. 61, No. 12, Dec. 1995, Walfridsson et al., “Xylose-MetabolizingSaccharomyces cerevisiaeStrains Overexpressing the TKL1 and TAL1 Genes Encoding the Pentose Phosphate Pathway Enzymes Transketolase and Transaldolase”, pp. 4184-4190.

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