Saccharomyces cerevisiae expressing M.sub.2 protein of influenza

Details Saccharomyces cerevisiae expressing M.sub.2 protein of influenza Saccharomyces cerevisiae expressing M.sub.2 protein of influenza

1995-11-09

1997-11-25

Ketter, James

Chemistry: molecular biology and microbiology

Micro-organism, per se ; compositions thereof; proces of...

Fungi

4353201, C12N 115, C12N 119

Patent

active

056911890

ABSTRACT:
A modified Saccharomyces cerevisiae cell, wherein the cell expresses the Influenza virus ion channel protein M.sub.2. Also disclosed is a process for detecting modulators of M.sub.2, which comprises (a) treating such modified Saccharomyces cerevisiae cells with a test substance, and (b) assessing growth in the presence of a test substance, wherein a change in growth signals that the test substance is an M.sub.2 modulator. M.sub.2 inhibitors are useful anti-viral agents.

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