Saccharoascorbic acid derivatives

Details Saccharoascorbic acid derivatives Saccharoascorbic acid derivatives

1991-07-19

1993-02-23

Ivy, C. Warren

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

549315, 549316, 549317, A01N 4320, A01N 4324, C07D30512, C07D30793

Patent

active

051890577

ABSTRACT:
A compound of the formula (I): ##STR1## wherein R.sub.1 and R.sub.2 each is a hydrocarbon residue, R.sub.3 is a sulfo group or phosphono group, --CO--R.sub.4 is an esterified carboxyl group, a thiol-esterified carboxyl group or an amidated carboxyl group; and .about. represents the absolute configuration of R or S, or its salt, which is useful for preventing and treating thrombosis.

REFERENCES:
patent: 5043459 (1991-08-01), Matsumura et al.
Plough et al., Biochimica et Biophysicia Acta, vol. 24, pp. 278-282 (1957).
Rijken et al., The Journal of Biological Chemistry, vol. 256, No. 13, (Jul. 10, 1981), pp. 7035-7041.
Jukes, Trends in Biochemical Sciences, vol. 4, No. 1 (Jan. 1979).
Pannell et al., Blood, vol. 67, No. 5 (May 1986) pp. 1215-1223.
Tengborn, Fibrinolysis, vol. 1 (1987) pp. 24-32.

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