Saccharin derivative proteolytic enzyme inhibitors

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

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Details

548210, 544135, 5142338, A61K 31425, A61K 31535, C07D41714, C07D41712

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active

053787200

ABSTRACT:
Compounds having the structural formula ##STR1## which inhibit the enzymatic activity of proteolytic enzymes, and processes for preparation thereof, method of use thereof in treatment of degenerative diseases and pharmaceutical compositions thereof are disclosed.

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patent: 4195023 (1980-03-01), Mulvey et al.
patent: 4276298 (1981-06-01), Jones et al.
patent: 5128339 (1992-07-01), Dunlap et al.
Sunket et al., J. Med. Chem. 31 1886-1890 (1988).

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