Saccharide derivatives and processes for their manufacture

Details Saccharide derivatives and processes for their manufacture Saccharide derivatives and processes for their manufacture

1987-01-16

1989-10-10

Griffin, Ronald W.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

536 171, 536 175, 536 179, A61K 3700

Patent

active

048733229

ABSTRACT:
Mono- and di-saccharidyl derivatives that are linked via a bridge member to a cephalin derivative, of the formula I, and processes for their manufacture are described. ##STR1## In the formula, R.sup.1 represents (a) aldohexosyl, (b) D-aldohexosyl that is glycosidically linked in the 4- or the 6-position to D-aldohexosyl, (c) aldopentosyl, (d) 6-deoxyaldohexosyl or (e) 2-acetylamino-2-deoxy-D-aldohexosyl, it being possible for free hydroxy groups present in the radicals mentioned under (a) to (e) above to be peracetylated, X represents oxygen or sulphur, Y represents alkylene having up to 10 carbon atoms in which from 1 to 3 non-terminal methylene groups may be replaced by oxygen, by carbonylimino or by carbonyloxy, R.sup.2 represents hydrogen, carboxy, lower alkoxycarbonyl, benzyloxycarbonyl or carbamoyl, R.sup.3 represents hydrogen and R.sup.4 represents a 1,2-dihydroxy-ethyl, 2-hydroxy-ethyl or hydroxymethyl group in which at least one hydroxy group is esterified by an unsubstituted aliphatic C.sub.10-24 -carboxylic acid and in which the other hydroxy group, if present, is free or esterified by an aliphatic C.sub.2-24 -carboxylic acid, or R.sup.3 and R.sup.4 each represents a hydroxymethyl group esterified by an unsubstituted aliphatic C.sub.10-24 -carboxylic acid. These compounds can be used as medicaments, for example for the prophylaxis and therapy of virus infections.

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