Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Carbohydrate doai
Patent
1997-11-14
2000-07-11
Peselev, Elli
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Carbohydrate doai
536 41, 536 172, 536 175, 536 176, 536 179, 536 53, 536 54, 536118, 536119, 514 25, 514 61, A61K 3170, C07H 1524
Patent
active
060873396
ABSTRACT:
Disclosed are novel saccharide derivatives which inhibit binding of toxins, such as heat-labile enterotoxin or cholera toxin, to their receptors either in vitro or in vivo. Additionally, disclosed are compounds which inhibit binding of enterovirulent organisms (e.g., bacteria, virus, fungi, and the like), such as Vibrio cholerae and enterotoxigenic strains of Escherichia coli, to their cell surface receptors.
REFERENCES:
patent: 4137401 (1979-01-01), Lemieux et al.
patent: 5580858 (1996-12-01), Ippolito et al.
patent: 5780603 (1998-07-01), Hindsgaul
Spangler, B.D., "Structure and Function of Cholera Toxin and Related Escherichia coli Heat-Labile Enterotoxin", Microbiological Reviews, 56(4):622-647 (1992).
Hol, W.G.J., et al., "Structure and Function of E. coli Heat-Labile Enteerotoxin and Cholera Toxin B Pentamer", Bacterial Toxins and Virulence Factors in Disease, Ed. by J. Moss et al., Marcel Dekker, Inc. (1995).
Evans et al., J. Amer. Chem. Soc., 112:4011-4030 (1990).
Pu et al., J. Org. Chem., 56:1280-1283 (1991).
Williams et al., J. Amer. Chem. Soc., 113:9276-9286 (1991).
Kagen et al., Synlett, 1990, 643-650.
E. Hasegawa, K. Ishiyama, T. Horaguchi, T. Shimizu, J. Org. Chem., 1991, 56, 1631-1635.
H. Paulsen, K.Eberstein, W. Koebernick, Tetrahedron Letters, 45-50, 4377-4380.
M. Dubois et al., Anal. Chem., 28, (1979) 350-356.
T. Mukaiyama et al., Tetrahedron Letters, 56, 5907-5908 (1968).
H. H. Westal et al., "Methods of Enzymology," 34(b), 64 (1974).
Svennerholm, A-M. et al., Current Microbiology, 1:19-23 (1978).
A. Hasagawa et al., J. Carbohydrate Chem., 5, 11-19 (1986).
D.W.K. Acheson et al., Infect. Immun., 61 (3), 1098-1104 (1993).
A. Ramesh et al., J. Biotechol., 43 (1), 45-51- (1995).
P. Fugedi et al., Glycocomjugate Journal, 4, 97-100 (1987).
E. Bar-Guilloux et al., Carbohydrate Research, 250 (1), 1-8 (1993).
M. Cerny et al., Collection of Czechoslovak Chemical Communications, 61 (10), 1489-1500 (1996).
G. Vic et al., Tetrahedron: Asymmetry, 5(12), 2513-1516 (1994).
J. DeFaye et al., Carbohydrate Research, 253, 185-194 (1994).
I. Tvaroska et al., Carbohydrate Research, 229 (2), 225-231 (1992).
M.-O. Contour-Galcera et al., Carbohydrate Research, 281 (1), 99-118 (1996).
M. Petrusova et al., Carbohydrate Research, 283, 73-80 (1996).
Witczak, Z.J. et al., Synthesis of L-Fucopyranosyl, 4-Thiodisacchasrides from Levoglucosenone and Their Inhibitory Activity on .beta.-L-Fucosidase, "Bioorganic & Medicinal Chemistry Letters", vol. 5, No. 18:2169-2174, 1995.
J. Defaye, et al., "Thiooligosaccharides: Their Synthesis and Reactions with Enzymes" in Studies in Natural Products Chemistry, vol. 8, pp. 315-357, Elsevier Sciences Publishers (1991).
Collins et al., "Monosaccharides: Their Chemistry and Their Roles in Natural Products," John Wiley & Sons, Chichester, England, 1995, pp. 97-106.
Ferrier et al., Carbohydrate Chemistry 1996, 28, 158-164.
Ferrier et al., Carbohydrate Chemistry 1993, 27, 140-147.
Williams et al., Carbohydrate Chemistry 1983, 17, 116-119.
Horton et al., Thio Sugars and Derivatives, In "The Carbohydrates: Chemistry and Biochemistry", 2.sup.nd Edition, Pigman et al., eds. Academic Press, New York, 1980.
Schnabeirauch et al, Helv. Chim. Acta 1994, 77, 778.
Peselev Elli
Synsorb Biotech Inc.
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