S type 2-substituted hydroxy-2-indolidinylbutyric ester compound

Details S type 2-substituted hydroxy-2-indolidinylbutyric ester compound S type 2-substituted hydroxy-2-indolidinylbutyric ester compound

1999-10-18

2000-09-05

Stockton, Laura L.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

546 18, C07D47120, C07D47122

Patent

active

061145297

ABSTRACT:
A process for preparing S type 2-substituted hydroxy-2-indolidinyl-butyric ester compound [II]: ##STR1## wherein R.sup.0 is residue of nitrogen-containing fused heterocyclic carboxylic acid having absolute configuration of "R"(in which the nitrogen atom is protected), R.sup.1 and R.sup.2 are lower alkyl group, and E is ester residue, which is useful as an intermediate for preparing camptothecin derivatives having antitumor activities, which comprises 2-ethylating 2-substituted hydroxy-2-indolidinylacetic ester compound [I]: ##STR2## wherein the symbols are as defined above.

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