S type 2-substituted hydroxy-2-indolidinylbutyric ester compound

Details S type 2-substituted hydroxy-2-indolidinylbutyric ester compound S type 2-substituted hydroxy-2-indolidinylbutyric ester compound

1998-10-15

2000-01-18

Stockton, Laura L.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

546 48, C07D47114, C07D47122

Patent

active

060159014

ABSTRACT:
A process for preparing S type 2-substituted hydroxy-2-indolidinyl-butyric ester compound [II]: ##STR1## wherein R.sup.0 is residue of nitrogen-containing fused heterocyclic carboxylic acid having absolute configuration of "R"(in which the nitrogen atom is protected), R.sup.1 and R.sup.2 are lower alkyl group, and E is ester residue, which is useful as an intermediate for preparing camptothecin derivatives having antitumor activities, which comprises 2-ethylating 2-substituted hydroxy-2-indolidinylacetic ester compound [I]: ##STR2## wherein the symbols are as defined above.

REFERENCES:
patent: 5053512 (1991-10-01), Wani et al.
Bioorganic & Medicinal Chemistry Letter, vol. 5, No. 24, pp. 3063-3066, 1995.
Journal of Medicinal Chemistry, 1986, vol. 29, pp. 2358-2363.
Journal of Medicinal Chemistry, 1980, vol. 23, pp. 554-560.
Journal of Medicinal Chemistry, 1991, vol. 34, pp. 98-107.
Organic Synthetic Chemistry, vol. 49, No. 11, pp. 1013-1020, 1991.
Ejima et al., "Antitumor Agents, Part 2. Asymmetric Synthesis of (S)-Camptothecin" No. 1, pp.27-31, XP002010690 (1990), J. Chem. Soc. Perkin Trans.
Mash et al., "Mechanistic Studies of Disastereoselective Cyclopropanation via Homochiral Ketals. 2. Studies with Conformationally Restricted 2-Cyclohexane-1-one Ketals", vol. 55, No. 7, pp.2055-2060, XP002054434 (1990), J. Org. Chem.
Ejima et al., "Asymmetric Synthesis of (S)-Camptothecin" Tetrahedron Lett, vol. 30, No. 20, pp.2639-2640, XP002054435 (1989).
Ejima et al., "Antitumor Agents v. Synthesis and Antileukemic Activity of E-Ring-Modified (RS)-Camptothecin Analogues" Chem. Pharm. Bull., vol. 40, No. 3, pp. 683-688, XP000653713 (1992).
Wall et al., J. Med. Chem., vol. 29, No. 8, 1986, pp. 1553-1555.
Wani et al., J. Med. Chem., vol. 30, No. 12, 1987, pp. 2317-2319.
Patent Abstracts of Japan, vol. 016, No. 528, Oct. 29, 1992 (Publication No. 04200393 dated Jul. 21, 1992).
Patent Abstracts of Japan, vol. 016, No. 528, Oct. 29, 1992 (Publication No. 04200392 dated Jul. 21, 1992).
Ejima et al., Chem. Pharm. Bull., vol. 37, No. 8, 1989, pp. 2253-2255.
Terasawa et al., Chem. Pharm. Bull., vol. 37, No. 12, 1989, pp. 3382-3385.
Jew et al., Tetrahedron: Asymmetry, vol. 6, No. 6, 1995, pp. 1245-1248.
Kurihara et al., J. Heterocycl. Chem., vol. 30, No. 3, 1993, pp. 643-652.

Affiliated with

Also associated with

Rating

S type 2-substituted hydroxy-2-indolidinylbutyric ester compound does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with S type 2-substituted hydroxy-2-indolidinylbutyric ester compound, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and S type 2-substituted hydroxy-2-indolidinylbutyric ester compound will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-564278